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method of generating different types of vascular smooth muscle cells (SMCs) – the cells which make up the walls of blood vessels - using cells from patients s skin. This work could lead to new treatments and better screening for cardiovascular disease.
The team from the University of Cambridge worked with embryonic stem cells and reprogrammed skin cells, collectively known as human pluripotent stem cells (hPSCs), which have the potential to form any cell type in the body. They discovered a method of creating all the major vascular smooth muscle cells in high purity using hPSCs which can also be easily scaled up for production of clinical-grade SMCs. This is the first time that such a system has been developed and will open the door for comparative studies on different subtypes of SMCs to be carried out, which are otherwise extremely difficult to obtain from patients.
- Christine Cheung; Cambridge Uni.
- Alan Colman; A*STAR>
Institute of Medical Biology
- Lim Khiang Wee;
A*STAR Graduate Academy
http://www.a-star.edu.sg/Media/News/PressReleases/tabid/828/articleType/ArticleView/articleId/1594/Default.aspx
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