Main > PHARMA. > Process Chemistry. > Palladium Catalyst Residue Removal > Co.: UK. G. (Novel Method) > Work Description

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Researchers were optimizing a 20-L Suzuki-Miyaura coupling reaction to make a key phenylindole synthetic intermediate, and as is typical in pharmaceutical synthesis, they needed a simple and fast method to obtain high-purity product. The team tried several standard commercially available palladium scavengers such as activated carbon, amine-modified silicas, and trimercaptotriazine. But under their reaction conditions, none of those strategies came close to achieving the 150-ppm palladium target for the crystallized product. The researchers then turned to extraction methods and discovered that adding toluene to the reaction mixture followed by a 20% aqueous sodium bisulfite (NaHSO3) wash at 60 °C reduced the palladium level to 100 ppm


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