Main > ENDOCRINOLOGY > Diabetes. Treatment > Incretin Mimetics (GLP-1 Analogs) > GLP-1. Fluorinated > Org.: USA. T. (Research) > Work Description

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group presented a poster highlighting progress on fluorinating a different type of protein, the gut hormone glucagon-like peptide-1 (GLP-1). This peptide has potential as a drug to treat diabetes and, like other peptides, suffers rapid degradation by proteases, leaving it with a half-life in blood of only a few minutes. A nonfluorinated GLP-1 mimic named exenatide), which is derived from the saliva of the gila monster, has increased stability to proteases and already is being marketed to treat type 2 diabetes.

researchers replaced one or two amino acid residues in GLP-1 with hexafluoroleucine. Like fluorogainin-1, fluorinated GLP-1 proved to have enhanced enzymatic stability over the native version while preserving its biological activity. It also proved to be an effective binder of the GLP-1 receptor and is just as effective as the exenatide analogs



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