Main > ORGANIC CHEMICALS > ASymmetric Synthesis > Biginelli Reaction > Org.: CN. N. (Catalyst) > Work Description

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Catalyzed by ytterbium triflate & a chiral hexadentate ligand. They applied the optimized protocol to monastrol, a small molecule inhibitor of mitosis. The reaction of m-hydroxy
benzaldehyde, acetoacetate, & thiourea yielded (R)-monastrol in 99% ee.


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