Main > COMBINATORIAL. CHEMISTRY > Fluorous Mixture Synthesis (FMS) > Co.: USA. F. (Brand/Tech./Patents) > NonPatent Literature Description

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technique known as fluorous mixture synthesis to prepare stereoisomer libraries of natural products. "This is a cutting-edge technique for making multiple compounds in a single reaction flask". "While we do synthesis on mixtures, the final demixing allows us to isolate individual pure compounds at the end."

With this technique, members of a series of substrates are tagged with different fluorous tags, mixed, and taken through a series of reactions. The tagged products are then separated by fluorous high-pressure liquid chromatography using a fluorous silica gel column. The products elute in order of the size of the fluorous tag, from C2F5 up to C8F17. They are finally detagged to obtain the pure compounds.




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