Main > A1. CORP. INDEX. S-Sm > Senomyx Inc/P > 2005. 08.15.2005. Sweet Taste Model

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A group based at Senomyx, a flavorings biotech company in La Jolla, Calif., reported earlier that the perception of sweetness depends totally on the heterodimeric G-protein-coupled receptor (GPCR) T1R2-T1R3, suggesting that it was the sole sweet-taste receptor. Temussi and coworkers have now modeled T1R2-T1R3 by comparing it with the glutamate receptor, a better understood GPCR of similar sequence, and have calculated the way sweeteners bind to the receptor.

The model reveals four binding sites that can be occupied independently. Small-molecule sweeteners bind to an extracellular pocket on each of the subunits or a site on the receptor s transmembrane domain, and sweet proteins can bind to a "wedge site" above one of the pockets.




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