Main > COMBINATORIAL. CHEMISTRY > CarboHydrates. > Org.: USA. M. (Research) > Research Report

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Author bringing difficult-to-synthesize carbohydrates into the combinatorial fold. The researchers use automated solid-phase oligosaccharide synthesis to create large collections of complex carbohydrates from monosaccharide building blocks. Author s automated carbohydrate synthesizer delivers solvents and reagents to a reaction chamber where sugar building blocks are combined with support-bound carbohydrates in a programmed manner. After several cycles, oligosaccharide products are born. Author have validated their synthetic approach by constructing only a small number of glycosaminoglycan variants in solution phase. But their first automated runs are under way



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