Main > NEUROLOGY. > Alzheimer's Disease > Treatment > Dynamin 1 (Protein) Enhancers > Org.: USA. N. (Research) > Report Abstract

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Protein loss and early Alzheimer s

Depletion of the protein dynamin 1 in neurons may explain the early cognitive declines that show up in Alzheimer s patients before any visible damage to the structure of the brain. Dynamin 1 is essential for proper functioning of the brain s synapses and for memory formation and information processing. In tests with neural cells and with a mouse model of Alzheimer s disease, the researchers have found that the amyloid-ß protein--which aggregates into plaques as the disease progresses--reduces dynamin 1 levels. Author s team has shown that amyloid-ß may act through two possible routes: It abnormally activates calpain, a protein that cleaves dynamin 1, and it may also decrease production of dynamin 1. Drugs that inhibit calpain or increase production of dynamin 1 could be useful in treating Alzheimer s disease, the team suggests.




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