Main > IMMUNOLOGY > Vaccines > Rotavirus Vaccine (GastroEnteritis) > Co.: USA. M. Approved > Description>
Live, oral pentavalent vaccine that contains 5 live reassortant rotaviruses. The rotavirus parent strains of the reassortants were isolated from human and bovine hosts. Four reassortant rotaviruses express one of the outer capsid proteins (G1, G2, G3, or G4) from the human rotavirus parent strain and the attachment protein (P7) from the bovine rotavirus parent strain. The fifth reassortant virus expresses the attachment protein, P1A (genotype P[8]), hereafter referred to as P1[8], from the human rotavirus parent strain and the outer capsid protein G6 from the bovine rotavirus parent strain.
The reassortants are propagated in Vero cells using standard cell culture techniques in the absence of antifungal agents.
The reassortants are suspended in a buffered stabilizer solution. Each vaccine dose contains sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, and trace amounts of fetal bovine serum. There are no preservatives or thimerosal present.
Pale yellow clear liquid that may have a pink tint.
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