Main > NEUROLOGY. > AntiDepressant > SSRI Type AntiDepressant > Sertraline. > Sertraline.HCl Salt > Co.: USA. P (Brand Dosage/Patent) > Process Chemistry

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One example presented as a case study is the significant improvement in Co. s manufacturing process for sertraline, the active ingredient in the antidepressant drug. The primary change in the sertraline synthesis was reducing a three-step sequence to a single step by designing reactions that do not require isolation and purification of intermediates, he said.

Overall, the process changes improved the yield, used environmentally friendlier solvents, and reduced the solvent requirements from 60,000 to 6,000 gal per ton of sertraline. On an annual basis, 440 metric tons of titanium dioxide waste, 150 metric tons of 35% hydrochloric acid waste, and 100 metric tons of 50% sodium hydroxide waste also were eliminated. Co. received a 2002 Presidential Green Chemistry Challenge Award for the improved process.




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