Main > ENDOCRINOLOGY > Diabetes. Treatment > Insulin. > Delivery (Except Inj.) > NanoTechnology > Gold Shell/Silica Core PhotoThermal > Org.: USA. R (Patents) > Literature Description

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In the area of drug delivery, Author is directing research using nanoshell systems for drug delivery. The nanoshells are tiny spheres with dielectric silica cores covered with a layer of gold nanoparticles.

The key for using these nanoshells for drug delivery is their tunable optical wavelength properties. This tunablity is dependent on the gold nanoshell thickness and has been varied by Author and her fellow researchers to fall in the near-infrared wavelength region--a region where human blood and tissue are relatively transparent.

Author discussed a system for insulin delivery in which these tunable nanoshells are embedded into thermoresponsive polymers. The polymers form a capsulelike pod in which insulin (or another drug) can be contained. When light of the proper wavelength irradiates the polymer, however, the embedded nanoshells heat up and in turn activate the polymer, which causes it to collapse and release the insulin.




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