Main > ORGANIC CHEMICALS > Aromatics > Phloroglucinol > Org.: USA. M (BioSynthesis) > BioSynthesis Description

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Author has identified the enzyme from Pseudomonas fluorescens that strings three molecules of malonyl coenzyme A (top) into what is possibly an activated diketoheptanedioate (middle, R = an active-site residue or CoA), which is subsequently cyclized. Aromatization to phloroglucinol (bottom) would occur spontaneously, Author says. By expressing the enzyme in Escherichia coli, the team has produced phloroglucinol from glucose in fermentors in yields of up to 10 g per L


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