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Metal complexes catalyze gentle transamidation

The first metal complexes that efficiently catalyze transamidation--a novel class of amide-exchange reactions--under moderate conditions have been discovered by AUTHORS. Carboxamide bonds like those found in proteins and nylon polymers are remarkably robust and require harsh conditions or enzymes to be broken. But AUTHORS have found that titanium and aluminum amides can catalyze equilibrium transamidation reactions (shown) under moderate conditions. The catalytic activity of these complexes varies with the nature of the reactants nitrogen substituents, suggesting that it may be possible to develop catalysts with functional group selectivity. The team is now working to do just that, as well as to improve catalytic activity. "This discovery points toward amides as a new class of substrates for dynamic covalent chemistry" and will enable the synthesis of new amide-based molecules and polymers under equilibrium-controlled conditions, AUTHOR tells.




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