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Metal catalyst promotes [2+2] cycloaddition

Alkene [2+2] cycloadditions are typically photochemically induced and generally exhibit poor stereoselectivity. Now, a catalyst has been developed that can extend [2+2] cycloaddition methodology to photochemically fragile substrates, enabling a new technique for the synthesis of fused cyclobutane-containing natural products. AUTHOR, have developed a highly stereoselective cobalt catalyst for the intramolecular [2+2] cycloaddition of bis-enones to form substituted bicyclo[3.2.0] ring systems. The reaction is viable for a variety of substituted bis-enones, but it requires at least one aromatic enone partner. In each case, independent of the alkene geometry of the starting bis-enone, [2+2] cycloadducts are formed as single stereoisomers



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