Main > NEUROLOGY. > Alzheimer's Disease > Treatment > Nicotine Mimics > Org.: USA. U (Anti-Inflammatories) > NPLS Contents

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New results from the Org., suggest that a similar control mechanism might exist in the brain. AUTHORS show that the Alpha7 receptor can be found on the brain s microglial cells, which mediate immune response in the central nervous system.
Microglia in patients with diseases such as Alzheimer s and Parkinson s become excessively active, which “gives rise to persistent inflammation, resulting in exacerbation of neurodegeneration,” the team hypothesizes.

Smoking appears to provide some protection against such diseases. The researchers believe binding of nicotine to the glial cells Alpha7 receptors suppresses their inflammatory activity. Thus, mimics of nicotine that avoid its side effects could potentially be used as preventatives for neurodegenerative diseases.



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