Main > NEUROLOGY. > Alzheimer's Disease > Beta Secretase [BACE1 (Abbrev.)] > Aspartyl Protease 2 (Asp2). > Patent > Claims Etc > Claim 1: Isolated Polynucleotide > Nucleotide Seq. Hybridizes under > Following Stringent Hybridization > Conditions to Complement of SEQ ID > NO:3: (1) Hybridization at 42C; > Buffer: 6.times.SSC and 0.1% SDS & > (2) Wash at 65C in Soln.: > 1.times.SSC and 0.1% SDS; Wherein > Polynucleotide Encodes Polypeptide > ; Contiguous AA Seq. Includes > Aspartyl Protease Active Site > Tripeptides DTG & DSG & Exhibits > Aspartyl Protease Activity Involved > in Processing APP into Amyloid Beta > Lacks a Transmembrane Domain. > Claim 2: Isolated Polynucleotide > ; Nucleotide Seq. Encoding Protein > Comprises Fragment of Asp2 AA Seq. > SEQ ID NO: 4; Contiguous Fragment > SEQ ID NO: 4 Includes Aspartyl > Protease Activity Involved in > Processing APP into Amyloid Beta & > Lacks a Transmembrane Domain. > Claim 3: Heterologous Peptide Tag > Claim 4: Isolated Polynucleotide > Nucleotide Seq. Encodes a Signal > Peptide Fused In-Frame to Polypepti > de Comprise Fragment of Asp2 Protei > n AA Seq. of SEQ ID NO: 4: Wherein > Continuous Fragment Includes

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Continuous Fragment Includes's subsections
Aspartyl Protease Active Site Tripe

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