Main > NEUROLOGY. > Alzheimer's Disease > Beta Secretase [BACE1 (Abbrev.)] > Aspartyl Protease 2 (Asp2). > Inhibitor. > Identification Method. > Patent. > Claims Etc > Claim 1: Method Identifying Agent > Modulates Activity of Asp2 Aspartyl > Protease, Comprising the Steps: a) > Contacting Asp2 Aspartyl Protease > with APP in Presence & Absence of > Test Agent; Asp2 Aspartyl Protease > Recombinant Polypeptide Exhibits > Asp2 Aspartyl Protease Activity > Involved in Processing APP into > Amyloid Beta & Expressed by Host > Cell Transformed with Nucleic Acid > Molecule that Encodes Polypeptide > , Hybridizes at Following Stringent > Hybridization Conditions to > Complement of SEQ ID NO: 3: (1) > Hybridization at 42C; Buffer: > 6.times.SSC & 0.1% SDS. (2) Wash > at 65C in Soln.: 1.times.SSC &

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at 65C in Soln.: 1.times.SSC &'s subsections
0.1% SDS; b) Determine APP

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