Main > NEUROLOGY. > Alzheimer's Disease > Beta Secretase [BACE1 (Abbrev.)] > Aspartyl Protease 2 (Asp2). > Inhibitor. > Identification Method. > Patent. > Claims Etc > Claim 1: Method Identifying Agent > Modulate Activity Asp2 Aspartyl > Protease Comprising Steps: a) > Contact Asp2 Aspartyl Protease with > APP in Presence & Absence of Test > Agent; Asp2 Aspartyl Protease is > ReCombinant protein Exhibits > Asp2 Aspartyl Protease Activity > Involved in Processing APP into > Amyloid Beta & Expressed by Host > Cell Transformed with Nucleic Acid > Molecule Encodes Protein & that > Hybridizes at Following Stringent > Hybridization Conditions to the > Complement of SEQ ID NO: 5: (1) > Hybridization at 42C in Buffer: > 6.times.SSC & 0.1% SDS & (2) Wash > at 65C in Soln.: 1.times.SSC & > 0.1% SDS; b) Determine APP > Processing Activity Asp2 Aspartyl > Protease in Presence & Absence of > Test Agent & c) Identify Test Agent > as Inhibitor if Protease Activity > is Decreased in Pres. of Test Agent > Claim 2: APP Beta-Secretase Cleavag > e Site Comprise: Swedish Mutation > (K.fwdarw.N, M.fwdarw.L). Claim 3: > Cl. 1a: Growing Transformed Cells > in Presence & Absence of Test Ag. > Claim 4: APP Expressed by Cell. > Claim 5: Cl. 4 Determining Step Com > prise Measuring Production of > Amyloid Beta Peptide by Cell in > Presence & Absence of Test Agent

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Presence & Absence of Test Agent's subsections
Claim 6: Host Cell:

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