Main > NEUROLOGY. > Alzheimer's Disease > PreSenilin (Protein) > PreSenilin-1. > (Gamma Secretase) > Mutated PreSenilin-1. > Patent > Claims Etc > Claim 1: Isolated Mutant PreSenilin > -1 Polypeptide Comprise SEQ ID NO:5 > ; Residue 386 Selected: Threonine & > Residue 387 Selected: Glycine; > Mutant PS-1 Preferentially Modulate > Processing of APP to Yield Increase > d Levels of A.Beta.-1-42 Relative > to A.Beta-1-40 when Compared to

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Wild Type PreSenilin-1 Polypeptide

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