Main > NEUROLOGY. > Alzheimer's Disease > Beta Secretase [BACE1 (Abbrev.)] > Aspartyl Protease 2 (Asp2). > Patent > Claims Etc > Claim 1: Isolated Polynucleotide > SEQ ID NO: 7. Claim 2: Vector. > Claim 3: Vector; Polynucleotide > Linked to Promoter to Promote > Expression Polypeptide Encoded > by Polynucleotide in Host Cell > Claim 4: Host Cell Transformed with > Vector (Cl. 3). Claim 5: Mammalian > Cell. Claim 6: Cl. 4 Host Cell > Expresses Polypeptide on Surface > Claim 7: Host Cell (Cl. 4) Transfec > ted with Nucleic Acid Comprising > Nucleotide Seq. Encodes APP > Includes 2 Carboxy-Terminal Lysine > Residues. Claim 8: Host Cell (Cl. 7 > ) Expresses Polypeptide & APP on > Surface. Claim 9: Murine Asp2 > Polypeptide Make Method: > Culturing Host Cell (Cl. 4) in > Culture Medium. Claim 10: > Purifying Polypeptide from Cell. > Claim 14: Idem to Cl. 7 Except > "After APP": or Fragment Thereof > Contg. Beta-Secretase Cleavage Site > Claim 16: Host Cell (Cl. 14); APP > Comprises Swedish Mutation > (K.fwdarw.N, M.fwdarw.L) Adjacent

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(K.fwdarw.N, M.fwdarw.L) Adjacent's subsections
to the Beta-Secretase Cleavage Site

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