| INDICATION'S | This data is not available for free |
| STATUS | Development |
| TECHNOLOGY |
The key to inactivation of amyloid-beta toxin by vaccination is to stimulate a strong antibody immune response that targets and inactivates or promotes the clearance of the toxin. The generation of such antibodies requires a T-cell response. Although beta amyloid contains epitopes that can stimulate such a T-cell response, these particular epitopes carry the risk of inducing harmful autoimmunity. In TradeMarked Technology, the harmful human beta amyloid specific T-cell epitopes are replaced with a safe T-cell epitope, such as bacterial Tetanus Toxoid, against which most people have been vaccinated. Moreover, by using only short fragments of the amyloid-beta toxin too small to contain T-cell epitopes, the immune response is more specific than when larger pieces are used, ensuring that only the toxin, rather than the Amyloid Precursor Protein, is targeted by the antibody. |
| UPDATE | 09.19.07 |
| COMPANY | This data is not available for free |
| PATENT NUMBER | This data is not available for free |
| PATENT TITLE |
CHIMERIC PEPTIDES AS IMMUNOGENS, ANTIBODIES THERETO, AND METHODS FOR IMMUNIZATION USING CHIMERIC PEPTIDES OR ANTIBODIES |
| PATENT ABSTRACT | The invention provides a chimeric peptide or mixture of chimeric peptides that can be formulated as an immunizing composition and used in a method for immunization of a mammal against an internal peptide cleavage product derived from a precursor or mature protein, for which the peptide cleavage product and the precursor or mature protein are self molecules. The chimeric peptide or peptides have an end-specific B cell epitope from a naturally-occurring internal peptide cleavage product of a precursor or mature protein, as a free N- or C- terminus, fused with or without spacer residues to a T helper cell epitope derived from a living source different from that of the internal peptide cleavage product |
| PATENT INVENTORS | This data is not available for free |
| PATENT ASSIGNEE | This data is not available for free |
|
Want more information ? Interested in the hidden information ? Click here and do your request. |