| RESEARCH |
Recently, Curran, chemistry professor Craig S. Wilcox, and colleagues devised a double separation tagging technique that combines fluorous tags and oligomeric ethylene glycol tags. The use of oligoethylene glycols as sorting tags for chromatography was first reported by Wilcox and coworker Serhan Turkyilmaz earlier this year (Tetrahedron Lett. 2005, 46, 1827). The Curran and Wilcox team used the double-tagging approach to prepare, in a single-solution-phase synthesis, a stereoisomer library of 16 murisolins--a class of natural products that exhibit powerful cell-killing effects. The team separated the 16-compound mixture into individual components by using a series of two demixings--one for each class of tag. IN RELATED WORK, Curran's group has used double fluorous tagging to synthesize a stereoisomer library of eight passifloricins. The compounds, polyhydroxylated lactones, are found in the resin of Passiflora foetida, or fetid passionflower. Passifloricins exhibit high activity against the parasites that cause leishmaniasis. |
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