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Similar to the blood-brain barrier, the eye has the blood-vitreous barrier that prevents drugs from being delivered systemically. If drops are placed in the eyes, the drug is diluted and swept into the bloodstream before it reaches its target, says Joseph R. Robinson, a professorof pharmaceutical chemistry at the University of Wisconsin, Madison. Robinson says several approaches are under investigation. For example, a portal could be cut in the sclera (the white outer coating) of the eye and a piece of rubber inserted that could be used to inject through. Another possibility is to inject a slowly eroding or diffusing system that would reduce the number of injections required. |
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