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The stumbling block for 8-oxoguanine was removed by Francis Johnson, a professor of chemistry and pharmacological sciences at the State University of New York, Stony Brook, who has carved a career out of making oligonucleotides containing defined DNA lesions. He worked out a synthetic strategy for 8-oxoguanine-containing oligonucleotides in the early '90s [Chem. Res. Toxicol. 5, 608 (1992)]. |
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