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Utah's David and medical geneticist Julian R. Sampson of the University of Wales College of Medicine have shown that there's a direct link between inherited defects in Myh--one of the enzymes that helps repair 8-oxoguanine lesions--and patients' propensity for contracting colon cancer [Nat. Genet., 30, 227 (2002). They found that members of a British family affected by multiple colorectal cancers have two different mutations in the gene coding for Myh. These two mutant forms of Myh both remove adenine mispaired with 8-oxoguanine much less efficiently than the wild-type enzyme does. |
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