| OBSERVATION'S |
An even more important cause of the metabolic syndrome may be insulin resistance, according to others, including Gerald M. Reaven, emeritus professor of medicine at Stanford University. According to Reaven, insulin resistance varies considerably from person to person. About half of the variability is due to genetics and half to lifestyle. In 1988, Reaven proposed that individuals with a cluster of abnormalities related to insulin resistance are at significantly higher risk for cardiovascular disease. He named the cluster of risk factors Syndrome X. As the list of abnormalities associated with insulin resistance expanded and the cardiovascular community acknowledged the importance of insulin resistance as a risk factor for heart disease, the cluster became known as the metabolic syndrome. Researchers agree that insulin resistance is central to the metabolic syndrome. |
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