| SYNTHESIS |
Synthesis of boronic acids is not trivial. Typically, an aryl compound is treated with butyllithium to form a lithiated aryl intermediate. Boronic acid then replaces the lithium, forming an arylboronic acid. Companies with expertise in this chemistry have grown their custom synthesis business from the ability to supply customer-specific boronic acid reagents. An example is Co., which has many years of experience in the organometallic chemistries used to produce boronic acids. It is now applying its expertise to the phosphine ligands, many of which are prepared also via organometallic chemistries, Co. says. With these complementary capabilities, the company hopes that customers will ask it to run the coupling reaction as well. |
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