| CORP. SALE | Naphthalene-2-(CH2-CH2-CO-Me)-6-(OMe) (I) |
| PATENT ASSIGNEE'S COUNTRY | Italy |
| UPDATE | 09.99 |
| PATENT ASSIGNEE | Secifarma SPA |
| PATENT CLAIMS |
Prepn process - Condensation of 6-methoxy-naphthaldehyde (II) & t-Bu ace toacetate (III) in cyclohexane solvent in presence of piperi dine acetate catalyst to give 3-t-butoxycarbonyl-4-(6'-me thoxy-2'-naphthyl)-but-3-en-2-one (IV) as E/Z mixt - Hydrogenation of (IV) in THF in presence of 1-3% 5% Pd catalyst contg 50% water to give 3-t-butoxycarbonyl-4-(6'- methoxy-2'-naphthyl)-butan-2-one (V) - Cleavage of (V) by acid catalysis in aromatic solvent to gi ve crude (II) - Recristallization of crude (II) with MeOH |
| PATENT PHOTOCOPY | Available on request |
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