| PATENT NUMBER | This data is not available for free |
| PATENT GRANT DATE | May 5, 1992 |
| PATENT TITLE |
Organosamarium catalysts for the hydroamination of olefins |
| PATENT ABSTRACT | The reaction of a samarium catalyst [.eta..sup.5 --(CH.sub.3).sub.5 C.sub.5 ].sub.2 Sm(THF).sub.2 with amino-olefins provides a straightforward route to a heterocyclic compound. Alternatively, the reaction of olefins with the samarium catalyst in the presence of an amine results in an aminoalkane |
| PATENT INVENTORS | This data is not available for free |
| PATENT ASSIGNEE | This data is not available for free |
| PATENT FILE DATE | March 13, 1990 |
| PATENT REFERENCES CITED |
Ambuehl et al., Journal of Organo Metallic Chemistry, 160 (1978) pp. 329-335. Pez et al., Pure and Applied Chemistry, 57 No. 12, (1985), pp. 1917-1926. Evans et al., "Organolanthanide Hydride Chemistry, etc.", J. Am. Chem. Soc. (1983), 105, pp. 1401-1403. Jeske et al., "Highly Reactive Organolanthanides,etc.", J. Am. Chem. Soc., (1985), 107, 8111-8118. Watson et al., "Homogeneous Leanthanide Compleses as Polymerization and Oligomerization Catalysts: Mechanistic Studies," ACS Symposium Series, 1983, 212, 459-479. Watson and Parshall, "Organolanthanides in Catalysts," Acc. Chem. Res., 1985, 18, 51-56. Mauermann, Sweptson, and Marks, "5f.sup.3 vs. 4f.sup.3 ". Routes to and Properties of Highly Reactive Neodymium (III) Hydrocarbyl and Hydride Complexes, Organometallics, 4, 200 (1985). Jeske, Schock, Swepton, Schumann, and Marks, "Highly Reactive Organolanthanides. Synthesis, Chemistry, and Structures of 4f Hydrocarbyls and Hydrides with Chelating Bis (Polymethylcyclopentadienyl) Ligands," J. Am. Chem. Soc., 1985, 107, 8103-8110. Jeske, Lauke, Mauermann, Schumann, and Marks, "Highly Reactive Organolanthanides. Systematic Routes to and Olefin Chemistry of Early and Late Bis (pentamethylcyclopentadienyl) 4f Hyudrocarbyl and Hydride Complexes," J. Am. Chem. Soc. 1985, 107, 8091-8103. Deeba, et al., "Direct Amination of Ethylene by Zeolite Catalysis," J. Chem. Soc. Chem. Commun. 1987, 562-563. Evans, William J., "Polyhedron Report No. 20: The Organometallic Chemistry of the Lanthanide Elements in Low Oxidation States," Polyhedron, 1987, vol. 6, No. 5, 803-835. Finke et al., "Organolanthanide and Organoactinide Additions Exhibiting Enhanced Reactivity. 4. Products Stoichiometry, and Preliminary Kinetic Studies of the Reaction of (C.sub.5 Me.sub.5) .sub.2 SM.sup.II OEt.sub.2 and (C.sub.5 Me.sub.5) .sub.2 Eu.sup.II OEt.sub.2 with Alkyl and Aryl Halides. Evidence of Importance of Electron Transfer in Atom-Abstraction Oxidative Additions," Organometallics, 1987, 6, 1356-1358. Megedus, et al., "Palladium-Assisted Amination of Olefins. A mechanistic Study," J. Am. Chem. Soc. 1984, 106, 7122-7126. Surzur et al., "Bicyclisations Radicalaires Des N-Chloroamines Ethyleniques," Tetrahedron Letter, 1974, No. 25, 2191-2194. Fagan et al., "Insertion of Carbon Monoxide into Metal-Nitrogen Bonds. Synthesis, Chemistry, Structures, and Structural Dynamics of Bis (pentamethylcyclopentadienyl) Organoactinide Dialkylamides and n.sup.2 -Carbamoyls", J. Am. Chem. Soc., 1981, 103, 2206-2220. Tamaru et al., "Urea as the Most Reactive and Versatile Nitrogen Nucleophile for the Palladium (2+)-Catalyzed Cyclization of Unsaturated Amines," J. Am. Chem. Soc., 1988, 110, 3994-4002. Pugin et al., "Palladium-Promoted Cyclization Reactions of Aminoalkenes," Journal of Organometallic Chemistry, 1981, 214, 125-133. Gasc et al., "Tetrahedron Report No. 144: Amination al Alkenes," Tetrahedron, 1983, vol. 39, No. 5, 703-731. Deeba et al., "Heterogeneous Acid-Catalyzed Animation of Isobutene to tert-Butylamine," J. Org. Chem. 1988, 53, 4594-4596. |
| PATENT PARENT CASE TEXT | This data is not available for free |
| PATENT CLAIMS |
We claim: 1. A method for hydroaminating an amino-olefin,, comprising contacting said amino-olefin with a catalyst under an inert atmosphere, said catalyst being selected from the group consisting of Cp'.sub.2 Sm(THF).sub.2 and Cp'.sub.2 Sm, where Cp'=.eta..sub.5 R.sub.5 C.sub.5, and R is selected from the group consisting of H, alkyl or aryl. 2. A method for hydroaminating an olefin to yield an amino alkane comprising contacting said olefin with a catalyst in the presence of an amine or under an ammonia atmosphere, said catalyst having a formula selected from the group consisting of Cp'.sub.2 Sm(THF).sub.2 and Cp'.sub.2 Sm, wherein Cp'=.eta..sup.5 R.sub.5 C.sub.5, R being selected from the group consisting of hydrogen, alkyl groups, and aryl groups. 3. The method of claim 2 wherein said amine is NH.sub.3. 4. The method of claim 1 wherein said amino-olefin is selected from the group consisting of: ##STR19## 5. The method of claim 2 wherein said catalyst is in a solvent selected from the group consisting of tetrahydrofuran, cyclohexane, toluene, benzene, and pentane. 6. The method of claim 2 wherein said catalyst is homogeneous. 7. The method of claim 2 wherein said catalyst is heterogeneous. 8. The method of claim 7 wherein said catalyst is adsorbed on an inorganic substrate selected from the group consisting of silica, silica gel, alumina, magnesium chloride, and magnesium oxide. 9. A method for hydroaminating an unsaturated monomer selected from the group consisting of amino-olefins and amino cyclic alkenes comprising the steps of dissolving said unsaturated monomer in a solvent with a catalyst selected from the group consisting of Cp'.sub.2 Sm(THF).sub.2 and Cp'.sub.2 Sm under an inert atmosphere, wherein Cp'=.eta..sup.5 R.sub.5 C.sub.5, R being selected from the group consisting of hydrogen, alkyl groups, and aryl groups. 10. The method of claim 9 wherein said solvent is toluene. 11. The method of claim 9 wherein said unsaturated monomer is selected from the group consisting of: ##STR20## 12. A method of claim 9 wherein said solvent is selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, and mixtures thereof. 13. A method of hydroaminating an amino-olefin, comprising the steps of.sub.2 (a) evacuating a reaction vessel; (b) adding a solvent to said reaction vessel; (c) adding a solution containing a catalyst selected from the group consisting of Cp'.sub.2 Sm(THF).sub.2 and Cp'.sub.2 Sm , wherein Cp'=.eta..sup.5 R.sub.5 C.sub.5, R being selected from the group consisting of hydrogen, alkyl groups, and aryl groups, to said reaction vessel; (d) maintaining pressure with an atmosphere selected from argon or nitrogen in said reaction vessel at approximately one atmosphere; (e) stirring the solvent and catalyst solution rapidly for several minutes; (f) transferring an amino-olefin to said mixture; and (g) heating the reaction vessel, whereby the amino-olefin forms into a cyclic compound which may be isolated. 14. The method of claim 13 wherein said catalyst solution has a solvent selected from the group consisting of tetrahydrofuran, cyclohexane, toluene, benzene, and pentane. 15. The method of claim 13 wherein said catalyst is homogeneous. 16. The method of claim 13 wherein said catalyst is heterogeneous. 17. The method of claim 16 wherein said catalyst is adsorbed on an inorganic substrate selected from the group consisting of silica, silica gel, alumina, magnesium chloride, and magnesium oxide. 18. A method for hydroaminating an unsaturated monomer selected from the group consisting of .alpha.-olefins and cycloalkenes comprising the steps of dissolving said unsaturated monomer in a solvent and contacting said olefin solution with a catalyst selected from the group consisting of Cp'.sub.2 Sm(THF).sub.2 and Cp'.sub.2 Sm, wherein Cp'=.eta..sup.5 R.sub.5 C.sub.5, R being selected rom the group consisting of hydrogen, alkyl groups, and aryl groups. 19. The method of claim 18 wherein said solvent is selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, and mixtures thereof. 20. The method of claim 18 wherein said solvent is toluene. 21. The method of claim 18 wherein said unsaturated monomer is selected from the group consisting of ethylene, propylene, 1-butene, butadiene, 1-hexene, 1,5-hexadiene, and 1-heptene. -------------------------------------------------------------------------------- |
| PATENT DESCRIPTION |
This application relates to catalysts and more particularly to a method for the hydroamination of olefins through the use of organosamarium catalysts. BACKGROUND OF THE INVENTION The catalytic addition of N-H bonds to olefins (eq.(I)) to yield amines is a process of potentially great technological importance. ##STR1## However, presently known catalyst systems, employing palladium, platinum, or alkali metal catalysts, can be relatively inefficient, having very low rates, poor catalyst lifetimes, poor selectivities, or requiring initial modification of the amine--e.g., tosylation. As a result, many current catalytic processes involve the conversion of alcohols to amines with the alcohol, which in turn, is prepared from the olefin. Such hydroamination reactions are exothermic, yet thus far have proven difficult to perform due to a lack of suitable catalysts and, to a lesser extent, unfavorable entropy effects. As a result, more attention has been paid to aminating olefins intramolecularly, and limited successes have been experienced in both stoichiometric and catalytic type reactions. A rapid efficient, direct process for the hydroamination of olefins would be beneficial. Organolanthanide catalysts have been found useful as noted in U.S. Pat. No. 4,668,773 to Marks and Mauermann, the organolanthanide complexes [.eta..sup.5 --(CH.sub.3).sub.5 C.sub.5 ].sub.2 MCl.sub.2 --Li](C.sub.2 H.sub.5).sub.2 O].sub.2.sup.+, M=La, Nd, Sm, Lu, with LiCH[Si(CH.sub.3).sub.3 ].sub.2 were shown to provide a straight-forward route to ether-free and halide-free bis(pentamethylcyclopentadienyl) lanthanide alkyls [.eta..sup.5 (CH.sub.3).sub.5 C.sub.5].sup.].sub.2 MCH[Si(CH.sub.3).sub.3 ].sub.2. Such [.eta..sup.5 (CH.sub.3).sub.5 C.sub.5 ].sub.2 MCH[Si(CH.sub.3).sub.3 ].sub.2 complexes react with H: under mild conditions to yield the corresponding hydrides [.eta..sup.5 (CH.sub.3).sub.5 (C.sub.5).sub.2 MH[.sub.2. These complexes have been found to be extremely active homogeneous olefin polymerization catalysts, as well as catalysts for olefin and acetylene hydrogenation. SUMMARY OF THE INVENTION Therefore, an object of the subject invention is the use of organolanthanide catalysts for use in hydroamination reactions. Another object of the subject invention is a shelf-stable environmentally acceptable organolanthanide catalyst and its use in a method for the hydroamination of olefins. A further object of the subject application is a method for the synthesis of an organosamarium catalyst and the use of the organosamarium catalyst to hydroaminate amino-olefins. These and other objects are attained in accordance with the subject invention wherein Cp'.sub.2 Sm(THF).sub.2 and Cp'.sub.2 Sm (Cp'=.eta..sup.5 --R.sub.5 C.sub.5, R=H, an alkyl or aryl group or any mixture thereof; THF=tetrahydrofuran), and more particularly bis(pentamethylcyclopentadienyl) samarium bis(tetrahydrofuran) are prepared as effective catalyst precursors for the hydroamination of olefins. The procedure of the subject invention comprises the oxidative addition of the amino-olefin to the catalyst, forming in the process one equivalent of samarium-allyl and one equivalent of samarium-hydride. These equivalents can further react in a second step with the amino-olefin to yield the catalytically active, known samarium-amido species. This species further reacts, via an olefin insertion, into Sm--N bond and a protonation step to yield the cyclized amine and to regenerate the active catalyst. Cp'.sub.2 Sm(THF).sub.2 and its related entity Cp'.sub.2 Sm have the distinct advantage of not only being an efficient catalytic agent, but also they are extremely easily prepared. These and other objects of the subject invention, together with additional features contributing thereto and advantages occurring therefore will be apparent from the following description of one embodiment of the invention when read in conjunction with the accompanying drawing wherein: The figure is a representation of the reaction pathway of the method of the subject invention. DETAILED DESCRIPTION OF THE INVENTION All operations were performed with rigorous exclusion of oxygen and moisture in flamed Schlenk-type glassware in a dual manifold Schlenk line or interfaced to a high vacuum (10.sup.-5 torr) system, or in a nitrogen or argon filled glovebox with a high capacity atmosphere recirculator. Argon, ethylene, propylene, dihydrogen, and deuterium gas were purified by passage through a supported MnO oxygen removal column and a molecular sieve column. Aliphatic hydrocarbon solvents were pretreated with concentrated H.sub.2 SO.sub.4, KMnO.sub.4 solution, MgSo.sub.4, and Na, 4.ANG. molecular sieves. All reaction solvents were distilled from Na/K/benzophenone under nitrogen and were condensed and stored in vacuo in bulbs on the vacuum line containing a small amount of [Ti(.eta..sup.5 --C.sub.5 H.sub.5).sub.2 Cl].sub.2 ZnCl.sub.2 as indicator. Cyclohexane and heptane were additionally vacuum transferred onto Na/K and stirred for at least a day before use in catalytic experiments. The olefins, all hexenes and cyclohexene, were purified by stirring over Na/K for at least 6 hours and were freshly vacuum transferred. The amines were purified by stirring over Na/K for 1/2 hour, followed by at least 3 successive vacuum transfers onto freshly activated 4.ANG. molecular sieves (at least 1 day each); and freshly vacuum transferred before use. Deuterated solvents were dried over Na/K and vacuum transferred before use. Pentamethylcyclopentadiene was prepared by the procedure set forth in Oroanometallics. 1984, 3, 819-821. I. Catalyst Syntheses In general, the Cp'.sub.2 Sm(THF).sub.2 complex may be prepared in one simple step. I.sub.2 Sm(THF).sub.2 +2KCp'.fwdarw.Cp'.sub.2 Sm(THF).sub.2 +2KI II. Hydroamination The anaerobic catalytic reaction of Cp'.sub.2 Sm(THF).sub.2 with a variety of dry, degassed amino olefins and alkenes (typically in 100-200-fold stoichiometric excess) proceeds to completion in hydrocarbon solvents such as benzene, toluene, cyclohexane, or pentane. The base-free adduct Cp'.sub.2 Sm may also be used as a catalyst with no significant difference in cyclization rates. The reactions may be conveniently monitored by NMR spectroscopy and the products may be identified by comparison with spectral data from the literature and/or with those of authentic samples. By supplying olefins to the Sm--N bond intramolecularly in an organosamarium compound, it is possible to have a large effective concentration of olefin around the amine, while at the same time reducing the disfavoring entropic factor referred to above when the reaction is performed intermolecularly. A. Synthesis of Heterocycles To investigate one aspect of olefin hydroamination and in furtherance of one embodiment of the subject invention, a variety of cyclized amines may be synthesized from amino olefins, as set forth in Examples 1 through 6 below when reacted with catalytic amounts of an organosamarium catalyst, Cp'.sub.2 Sm(THF).sub.2. The catalyst Cp'.sub.2 Sm(THF).sub.2 readily combines with olefins in a first step, thereby forming the expected organosamarium-allyl-complexes. The amido complexes all have the ability to intramolecularly insert an olefin into the resulting samarium-NHR bond. The insertion results in an alkyl complex which, in the presence of excess amine, is rapidly protonated, yielding an alkane, and reforming an amido compound. The combination of all the reactions set forth in the figure constitutes a catalytic cycle which demonstrates the key steps believed to be involved in forming a group of heterocyclic compounds. |
| PATENT EXAMPLES | available on request |
| PATENT PHOTOCOPY | available on request |
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