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One of the greatest challenges in drug delivery is the administration of macromolecules across the skin at therapeutic rates. He has received NIBIB funding to further the development of microscopic needles. According to author preliminary results show that arrays of microneedles can be etched from silicon and molded using metals and polymers by means of modifications to the microfabrication technology used to make integrated circuits. The needles are long enough to deliver drugs across the skin's outer layer but short enough to avoid hitting nerves, so they are painless. Microneedles for transdermal drug delivery, author says, could significantly impact medicine by providing painless injections and a user-friendly method for controlled delivery of compounds such as conventional drugs and macromolecules over hours to days. |
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