| MECHANISM OF ACTION | An individual's physiological and psychological vulnerability to stress may depend in part on genetic makeup. For instance, University of Pittsburgh psychiatry professor George S. Zubenko has found that variations in the gene for CREB are linked to susceptibility to depressive disorders in women--possibly offering one reason that more women than men experience depression [Mol. Psychiatry, 8, 611 (2003)]. Zubenko has identified several other chromosomal regions that may influence susceptibility to depressive disorders [Am. J. Med. Genet., 123B, 1 (2003)]. |
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