| DESCRIPTION |
We use our patented Proteome Mining process to screen, in a single assay, compounds or compound libraries against the thousands of protein targets captured by our proprietary affinity media. Using high throughput robotics, our Proteome Mining process can screen several hundred compounds simultaneously against thousands of targets all in a single day. During Proteome Mining, compounds compete in an equal and non-biased environment for the purine-binding site on each captured protein. If a compound has sufficient affinity for a captured protein, that protein is released or eluted from the affinity media and is then collected and prepared for further analysis. The exact identity of the target protein is determined by sequencing using high accuracy mass spectrometry and bioinformatics. The number of proteins released by a single compound indicates that compound's specificity and also may provide information about both therapeutic and potential toxicity targets. If a compound elutes only a single protein it is likely to be a highly selective inhibitor of just one target. However, if a compound elutes multiple proteins it is non-specific and is likely to inhibit multiple therapeutic or toxicity targets. |
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