| PATENT NUMBER | This data is not available for free |
| PATENT GRANT DATE | July 15, 1997 |
| PATENT TITLE |
Peptides having bradykinin antagonist action |
| PATENT ABSTRACT | Peptides of the formula I A-B-C-E-F-K-P-G-M-F'-I (I), wherein the terms A, B, C, E, F, K, P, G, M, F', and I are defined in the specification, have bradykinin antagonist action. Their therapeutic utility includes all pathological states which are mediated, caused or supported by bradykinin and bradykinin-related peptides |
| PATENT INVENTORS | This data is not available for free |
| PATENT ASSIGNEE | This data is not available for free |
| PATENT FILE DATE | June 7, 1995 |
| PATENT FOREIGN APPLICATION PRIORITY DATA | This data is not available for free |
| PATENT REFERENCES CITED |
Eichler et al., eds., Handbook of Experimental Pharmacology, vol. 25, pp. 53-55 (1970). Stewart, Handbook of Experimental Pharmacology, Erdos et al., ed. vol. 25,Supplement, pp. 227-272 (1979). Morrison and Boyd, Organic Chemistry, 3rd ed., pp. 1018-1021 (1974). Japan Kokai Tokko Koho, Chemical Abstract, 100: 138974K (1983), 8 pp. pp. 53-55 (1970). Barabe et al., Canadian Journal of Physiology and Pharmacology, vol. 62, No. 6, pp. 627-629 (1984). Vavrek et al., Peptides, vol. 6, pp. 161-164 (1985). Vavrek et al., Peptides, vol. 9, pp. 655-658 (1985). Vavrek et al., Chemical Abstracts, 105: 184127n (1986). Regoli et al., Chemical Abstracts, 105: 36276v (1986). Vavrek et al., Advances in Experimental Medicine and Biology, Part 198A, pp. 543-547 (1986). Henke et al., Chemical Abstracts, 114: 207831q (1991). Lyle et al., Journal of Medicinal Chemistry, vol. 34, No. 3, pp. 1230-1233 (1991). Wirth et al., Br. J. Pharmacol., vol. 102, pp. 774-777 (1991). Hock et al., Br. J. Pharmacol., vol. 102, pp. 768-774 (1991). |
| PATENT PARENT CASE TEXT | This data is not available for free |
| PATENT CLAIMS |
What is claimed is: 1. A peptide of the formula I A-B-C-E-F-K-P-G-M-F' I in which A is a.sub.1, a.sub.2, or a.sub.3, wherein a.sub.1) is hydrogen, (C.sub.1 -C.sub.8)-alkyl, (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.1 -C.sub.8)-alkoxycarbonyl or (C.sub.1 -C.sub.8 -alkylsulfonyl, in which in each case 1, 2 or 3 hydrogen atoms are optionally replaced by 1, 2 or 3 identical or different radicals selected from carboxyl, amino, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl, (C.sub.1 -C.sub.4)- alkoxycarbonyl, (C.sub.6 -C.sub.12)-aryl, and (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.5)-alkyl, or in which in each case 1 hydrogen atom is optionally replaced by a radical selected from (C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.1 -C.sub.4)-alkylsulfonyl, (C.sub.1 -C.sub.4)-alkylsulfinyl, (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.4)-alkylsulfonyl (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.4)-alkylsulfinyl, (C.sub.6 -C.sub.12)-aryloxy, (C.sub.3 -C.sub.9)-heteroaryl and (C.sub.3 -C.sub.9)-heteroaryloxy and 1or 2 hydrogen atoms are replaced by 1 or 2 identical or different radicals selected from carboxyl, amino, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl, (C.sub.1 -C.sub.4)-alkoxycarbonyl, (C.sub.6 -C.sub.12)-aryl and (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.5)-alkyl, or a.sub.2) is (C.sub.3 -C.sub.8)-cycloalkyl, carbamoyl, which may be optionally substituted on the nitrogen by (C.sub.1 -C.sub.6)-alkyl or (C.sub.6 -C.sub.12)-aryl, (C.sub.6 -C.sub.12)-aryl, (C.sub.7 -C.sub.18)-aryloyl, (C.sub.6 -C.sub.12)-arylsulfonyl, (C.sub.3 -C.sub.9)-heteroaryl or (C.sub.3 -C.sub.9)-heteroaryloyl, wherein for the radicals defined under a.sub.1) and a.sub.2) in each case aryl, heteroaryl, aryloyl, arylsulfonyl, and heteroaryloyl is optionally substituted by 1, 2, 3 or 4 identical or different radicals selected from carboxyl, amino, nitro, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkyl (C.sub.1 -C.sub.4)-alkoxy, halogen, cyano, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl and (C.sub.1 -C.sub.4)-alkoxycarbonyl, a.sub.3) is a radical of the formula II ##STR8## R.sup.1 is defined as A under a.sub.1) or a.sub.2); R.sup.2 is hydrogen or methyl, R.sup.3 is hydrogen or (C.sub.1 -C.sub.6)-alkyl which is optionally monosubstituted by amino, substituted amino, hydroxyl, carboxyl, carbamoyl, guanidino, substituted guanidino, ureido, mercapto, methylmercapto, phenyl, 4-chlorophenyl, 4-fluorophenyl, 4-nitrophenyl, 4-methoxyphenyl, 4-hydroxyphenyl, phthalimido, 4-imidazolyl, 3-indolyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl or cyclohexyl, wherein substituted amino is a compound of the formula --NH--A-- and substituted guanidino is a compound of the formula --NH--C(NH)--NH--A, in which A is defined under a.sub.1) or a.sub.2); B is a basic amino acid in the L- or D-configuration, which may be substituted in the side chain; C is a compound of the formula IIIa or IIIb ##STR9## in which G' independently of one another is a radical of the formula IV ##STR10## in which R.sup.4 and R.sup.5 together with the atoms carrying them form a heterocyclic monocyclic, bicyclic or tricyclic ring system having 2 to 15 carbon atoms, and n is 2 to 8; E is a radical of an aromatic amino acid; F is a radical of a neutral, acidic or basic, aliphatic or aromatic amino acid which may be substituted in the side chain, or is a direct bond; P is a radical of the formula V ((D)-Tic); ##STR11## G is as defined above for G' or is a direct bond; F' is a radical of a neutral, acidic or basic aliphatic or aromatic amino acid which may be substituted in the side chain, is a radical --NH--(CH.sub.2).sub.n --, with n=2 to 8, or is a direct bond; I is --OH, --NH.sub.2 or --NHC.sub.2 H.sub.5, wherein I is not directly bonded to P; K is a radical --NH--(CH.sub.2).sub.x --CO-- with x=1-4 or is a direct bond; and M is as defined for F, or a physiologically tolerable salt of said peptide. 2. A peptide of the formula I or salt as claimed in claim 1 in which B is Arg, Lys, Orn, 2,4-diamino-butyroyl or an L-homoarginine radical, wherein in each case the amino or guanidino group of the side chain may be substituted by A as defined under a.sub.1) or a.sub.2); C is a compound of the formula IIIa G'-G'-Gly (IIa) in which each G' independently is a radical of the formula IV ##STR12## in which R.sup.4 and R.sup.5 together with the atoms carrying them form a heterocyclic monocyclic, bicyclic or tricyclic ring system having 2 to 15 carbon atoms; E is a radical of an aromatic amino acid in the L- or D-configuration, which contains 6 to 14 carbon atoms in the aryl moiety as ring members, which is optionally substituted by halogen in the 2-, 3- or 4-position, tyrosine, O-methyltyrosine, 2-thienylalanine, 2-pyridylalanine or naphthylalanine; F is a direct bond or a radical of a neutral aliphatic or aromatic amino acid which may be substituted in the side chain; F' is a radical of a basic amino acid in the L- or D-configuration, wherein the guanidino group or amino group of the side chain may be replaced by A as defined under a.sub.1) or a.sub.2), or is a radical --NH--(CH.sub.2).sub.n -- with n=2 to 8; K is a radical --NH--(CH.sub.2).sub.x --CO-- with x=1-4 or is a direct bond; and M is Phe, Thia or a direct bond. 3. A peptide of the formula I or salt as claimed in claim 2 in which F' is Arg or Lys, wherein the guanidino group or amino group of the side chain may be replaced by A as defined under a.sub.1) or a.sub.2), or is a radical --NH--(CH.sub.2).sub.n -- with n=2 to 8; and G' is a heterocyclic monocyclic or bicyclic ring system having 3 or 4 carbon atoms if said ring system is monocyclic or having 7 to 9 carbon atoms if said ring system is bicyclic. 4. A peptide of the formula I or salt as claimed in claim 1 in which B is Arg, Orn or Lys, wherein the guanidino group or the amino group of the side chain is unsubstituted or is substituted by (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, wherein in each case the aryloyl, arylsulfonyl and heteroaryloyl radicals are optionally substituted by 1, 2, 3 or 4 identical or different radicals selected from carboxyl, amino, nitro, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, cyano, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl and (C.sub.1 -C.sub.4)-alkoxycarbonyl; E is phenylalanine, 2-chlorophenylalanine, 3-chlorophenylalanine, 4-chlorophenylalanine, 2-fluoro-phenylalanine, 3-fluorophenylalanine, 4-fluorophenylalanine, tyrosine, O-methyltyrosine or .beta.-(2-thienyl)alanine; F is Ser, hSer, Leu, Val, Nle, Thr, Gin, Trp, (D)Asn, Opr, (D)Ser, (D)Gln or a direct bond; F' is Arg, wherein the guanidino group of the side chain may be replaced by A as defined under a.sub.1) or a.sub.2), or is a radical --NH--(CH.sub.2).sub.n -- with n=2 to 8; K is a radical--NH--(CH.sub.2).sub.x --CO-- with x=1 or is a direct bond; M is a direct bond; and I is OH or NH.sub.2. 5. A peptide of the formula I or salt as claimed in claim 1 in which A is hydrogen, (D)- or (L)-H-Arg, (D)- or (L)-H-Lys or (D)- or (L)-H-Orn; B is Arg, Orn or Lys, wherein the guanidino group or the amino group of the side chain is optionally substituted by (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.12)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, wherein the aryloyl, arylsulfonyl and heteroaryloyl radicals are optionally substituted with 1, 2, 3 or 4 identical or different radicals selected from the group consisting of methyl, methoxy and halogen; C is Pro-Pro-Gly, Hyp-Pro-Gly or Pro-Hyp-Gly; E is Phe or Thia; F is Ser, hSer, Leu, Val, Nle, Thr, Gln, Trp, (D)Asn, Opr, (D)Ser, (D)Gln or a direct bond; K is a radical --NH--(CH.sub.2).sub.x --CO-- with x=1 or is a direct bond; M is a direct bond; G is a radical of the formula IV ##STR13## in which R.sup.4 and R.sup.5 together with the atoms carrying them form a heterocyclic monocyclic, bicyclic or tricyclic ring system having 2 to 15 carbon atoms; F' is Arg; and I is OH. 6. A peptide of the formula I or salt as claimed in claim 1 in which A is hydrogen, (D)- or (L)-H-Arg, (D)- or (L)-H-Lys or (D)- or (L)-H-Orn; B is Arg, Orn or Lys, wherein the guanidino group or the amino group of the side chain is optionally substituted by (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, wherein the aryloyl, arylsulfonyl and heteroaryloyl radicals are optionally substituted with 1, 2, 3 or 4 identical or different radicals selected from the group consisting of methyl, methoxy and halogen; C is Pro-Pro-Gly, Hyp-Pro-Gly or Pro-Hyp-Gly; E is Phe or Thia; F is Ser or a direct bond; K is a direct bond or --NH--(CH.sub.2).sub.x --CO-- with x=1-4, wherein when F is serine, K is a direct bond, and when K is --NH--(CH.sub.2).sub.x --CO--, F is a direct bond; M is a direct bond; G is a radical of the formula IV ##STR14## in which R.sup.4 and R.sup.5 together with the atoms carrying them form a heterocyclic monocyclic, bicyclic or tricyclic ring system having 2 to 15 carbon atoms; F' is Arg; and I is OH. 7. A peptide of the formula I or salt as claimed in claim 1 in which A is hydrogen, (D)- or (L)-H-Arg, (D)- or (L)-H-Lys or (D)- or (L)-H-Orn; B is Arg, Orn or Lys, wherein the guanidino group or the amino group of the side chain is optionally substituted by (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, wherein the aryloyl, arylsulfonyl and heteroaryloyl radicals are optionally substituted with 1, 2, 3 or 4 identical or different radicals selected from the group consisting of methyl, methoxy and halogen; C is Pro-Pro-Gly, Hyp-Pro-Gly or Pro-Hyp-Gly; E is Phe or Thia; F is Cys K is a radical --NH--(CH.sub.2).sub.x --CO-- with x=1 or is a direct bond; M is a direct bond; G is a radical of the formula IV ##STR15## in which R.sup.4 and R.sup.5 together with the atoms carrying them form a heterocyclic monocyclic, bicyclic or tricyclic ring system having 2 to 15 carbon atoms, F' is Arg; and I is OH. 8. A peptide of the formula I or salt as claimed in claim 5, in which G is a radical selected from the group consisting of pyrrolidine (A), piperidine (B), tetra-hydroisoquinoline (C), cis- and trans-decahydroisoquinoline (D), cis-endo-, cis-exo, and trans-octahydroindole (E), cis-endo-, cis-exo-, and trans-octa-hydrocyclopentano[b]pyrrole (F), and hydroxyproline (V). 9. A peptide of the formula I or salt as claimed in claim 6, in which G is a radical selected from the group consisting of pyrrolidine (A), piperidine (B), tetra-hydroisoquinoline (C), cis- and trans-decahydroisoquinoline (D), cis-endo-, cis-exo, and trans-octahydroindole (E), cis-endo-, cis-exo-, and trans-octa-hydrocyclopentano[b]pyrrole (F), and hydroxyproline (V). 10. A peptide of the formula I or salt as claimed in claim 1, in which A is hydrogen or D-Arg, B is Arg, Arg(NO.sub.2) or Arg(Tos), C is Hyp-Pro-Gly, Pro-Hyp-Gly, or Pro-Pro-Gly E is Thia or Phe, F is Ser, K is a direct bond, G is Aoc, Tic or Oic, M is a direct bond, F' is Arg, and I is OH. 11. A peptide of the formula I or salt as claimed in claim 1, in which A is hydrogen or D-Arg, B is Arg or Arg(Tos), C is Pro-Hyp-Gly, E is Thia, F is Ser, K is a direct bond, G is Aoc or Oic, M is a direct bond, F' is Arg, and I is OH. 12. A peptide of the formula H-D-Arg-Arg-Hyp-Pro-Gly-Phe-Ser-D-Tic-Oic-Arg-OH, H-D-Arg-Arg-Pro-Pro-Gly-Phe-Ser-D-Tic-Oic-Arg-OH, H-D-Arg-Arg-Hyp-Pro-Gly-Thia-Ser-D-Tic-Aoc-Arg-OH, H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Aoc-Arg-OH, H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Tic-Arg-OH, H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Aoc-Arg-OH, H-D-Arg-Arg-Pro-Pro-Gly-Thia-Ser-D-Tic-Oic-Arg-OH, H-D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Tic-Oic-Arg-OH, H-D-Arg-Arg(NO.sub.2)-Pro-Hyp-Gly-Phe-Ser-D-Tic-Aoc-Arg-OH, or H-Arg(Tos)-Pro-Hyp-Gly-Thia-Ser-D-Tic-Oic-Arg-OH, or a physiologically tolerable salt of said peptide. 13. A peptide of the formula H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Aoc-Arg-OH, H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Oic-Arg-OH, or H-Arg (Tos)-Pro-Hyp-Gly-Thia-Ser-D-Tic-Oic-Arg-OH, or a physiologically tolerable salt of said peptide. 14. A peptide of the formula H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Oic-Arg-OH or a physiologically tolerable salt of said peptide. 15. A peptide of the formula I A-B-C-E-F-K-P-G-M-F'-I (I) in which A a.sub.1) is hydrogen, (C.sub.1 -C.sub.8)-alkyl, (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.1 -C.sub.8)-alkoxycarbonyl or (C.sub.1 -C.sub.8)-alkylsulfonyl, in which in each case 1, 2 or 3 hydrogen atoms are optionally replaced by 1, 2 or identical or different radicals selected from carboxyl, amino, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl, (C.sub.1 -C.sub.4)-alkoxycarbonyl, (C.sub.6 -C.sub.12)-aryl, and (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.5)-alkyl, or in which in each case 1 hydrogen atom is optionally replaced by a radical selected from (C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.1 -C.sub.4)-alkylsulfonyl, (C.sub.1 -C.sub.4)-alkylsulfinyl, (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.4)-alkylsulfonyl (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.4)-alkylsulfinyl, (C.sub.6 -C.sub.12)-aryloxy, (C.sub.3 -C.sub.9)-heteroaryl and (C.sub.3 -C.sub.9)-heteroaryloxy and 1or 2 hydrogen atoms are replaced by 1 or 2 identical or different radicals selected from carboxyl, amino, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, di-(C.sub.1 -.sub.4)-alkylamino, carbamoyl, sulfamoyl, (C.sub.1 -C.sub.4)-alkoxycarbonyl, (C.sub.6 -C.sub.12)-aryl, and (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.5)-alkyl, a.sub.2) is (C.sub.3 -C.sub.8)-cycloalkyl, carbamoyl, which may be optionally substituted on the nitrogen by (C.sub.1 -C.sub.6)-alkyl or (C.sub.6 -C.sub.12)-aryl, (C.sub.6 -C.sub.12)-aryl, (C.sub.7 -C.sub.18)-aryloyl, (C.sub.6 -C.sub.12)-arylsulfonyl, (C.sub.3 -C.sub.9)-heteroaryl or (C.sub.3 -C.sub.9)-heteroaryloyl, wherein for the radicals defined under a.sub.1) and a.sub.2) in each case aryl, heteroaryl, aryloyl, arylsulfonyl and heteroaryloyl is optionally substituted by 1, 2, 3 or 4 identical or different radicals selected from carboxyl, amino, nitro, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, cyano, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl and (C.sub.1 -C.sub.4)-alkoxycarbonyl, or a.sub.3) is a radical of the formula II ##STR16## R.sup.1 is defined as A under a.sub.1) or a.sub.2), R.sup.2 is hydrogen or methyl, R.sup.3 is hydrogen or (C.sub.1 -C.sub.6)-alkyl which is optionally monosubstituted by amino, substituted amino, hydroxyl, carboxyl, carbamoyl, guanidino, substituted guanidino, ureido, mercapto, methylmercapto, phenyl, 4-chlorophenyl, 4-fluorophenyl, 4-nitrophenyl, 4-methoxyphenyl, 4-hydroxyphenyl, phthalimido, 4-imidazolyl, 3-indolyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl or cyclohexyl, wherein substituted amino is a compound of the formula --NH--A-- and substituted guanidino is a compound of the formula --NH--C(NH)--NH--A, in which A is defined under a.sub.1) or a.sub.2); B is a basic amino acid in the L- or D-configuration, which may be substituted in the side chain; C is a compound of the formula IIIa or IIIb ##STR17## in which each G' independently is a radical of the formula IV ##STR18## in which R.sup.4 and R.sup.5 together with the atoms carrying them form a heterocyclic monocyclic, bicyclic or tricyclic ring system having 2 to 15 carbon atoms, and n is 2 to 8; E is a radical of an aromatic amino acid; F is a radical of a neutral, acidic or basic, aliphatic or aromatic amino acid which may be substituted in the side chain, or is a direct bond; P is D-phenylalanine ((D)-Phe) which may be optionally substituted in the phenyl moiety; G is a radical of the formula IV in which R.sub.4 and R.sub.5 together with the atoms carrying them form a heterocyclic bicyclic or tricyclic ring system having 7 to 15 carbon atoms; F' is a radical of a neutral, acidic, or basic aliphatic or aromatic amino acid which may be substituted in the side chain, or is a radical --NH--(CH.sub.2).sub.n --, with n=2 to 8, or is a direct bond; I is --OH, --NH.sub.2 or --NHC.sub.2 H.sub.5 ; K is a radical --NH--(CH.sub.2).sub.x --CO-- with x=1-4 or is a direct bond, and M is as defined for F, or a physiologically tolerable salt thereof. 16. A peptide of the formula I or salt as claimed in claim 15 in which B is Arg, Lys, Orn, 2,4-diaminobutyroyl or an L-homoarginine radical, wherein in each case the amino or guanidino group of the side chain may be substituted by A as defined under a.sub.1) or a.sub.2); C is a compound of the formula IIIa ##STR19## in which each G' independently is a radical of the formula IV ##STR20## in which R.sup.4 and R.sup.s together with the atoms carrying them form a heterocyclic monocyclic, bicyclic or tricyclic ring system having 2 to 15 carbon atoms; E is a radical of an aromatic amino acid in the L- or D-configuration, which contains 6 to 14 carbon atoms in the aryl moiety as ring members, which is optionally substituted by halogen in the 2-, 3- or 4-position, tyrosine, O-methyltyrosine, 2-thienylalanine, 2-pyridylalanine or naphthylalanine; P is D-Phe which is optionally substituted in the phenyl moiety by halogen or (C.sub.1 -C.sub.4)-alkoxy; F' is a radical of a basic amino acid in the L- or D-configuration, wherein the guanidino group or amino group of the side chain may be replaced by A as defined under a.sub.1) or a.sub.2), or is a radical --NH--(CH.sub.2).sub.n -- with n=2 to 8; G is a radical of the formula IV in which R.sup.4 and R.sup.5 together with the atoms carrying them form a heterocyclic bicyclic ring system having from 7 to 9 carbon atoms; F is a direct bond or a radical of a neutral aliphatic or aromatic amino acid which may be substituted in the side chain; and K is a direct bond. 17. A peptide of the formula I or salt as claimed in claim 16 in which F' is Arg or Lys, wherein the guanidino group or amino group of the side chain may be replaced by A as defined under a.sub.1) or a.sub.2), or is a radical --NH--(CH.sub.2).sub.n -- with n=2 to 8; G is a heterocyclic radical selected from octahydroindole (E), octahydrocyclopenta[b]pyrrole (F), deca-hydrocyclohepta[b]pyrrole (N), octahydroisoindole (O), and decahydroisoquinoline (D); and G' is a heterocyclic monocyclic or bicyclic ring system having 4 or 5 carbon atoms if said ring system is monocyclic or having 7 to 9 carbon atoms if said ring system is bicyclic. 18. A peptide of the formula I or salt as claimed in claim 15 in which B is Arg, Orn or Lys, wherein the guanidino group or the amino group of the side chain is unsubstituted or is substituted by (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 C.sub.18)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, wherein in each case the aryloyl, arylsulfonyl and heteroaryloyl radicals are optionally substituted by 1, 2, 3 or 4 identical or different radicals selected from carboxyl, amino, nitro, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, cyano, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl and (C.sub.1 -C.sub.4)-alkoxy-carbonyl; C is a compound of the formula IIIa ##STR21## in which each G' independently is a radical of the formula IV ##STR22## in which R.sup.4 and R.sup.5 together with the atoms carrying them form a heterocyclic monocyclic, bicyclic or tricyclic ring system having 2 to 15 carbon atoms; E is phenylalanine, 2-chlorophenylalanine, 3-chlorophenylalanine, 4-chlorophenylalanine, 2-fluorophenylalanine, 3-fluorophenylalanine, 4-fluorophenylalanine, tyrosine, O-methyltyrosine or .beta.-(2-thienyl)-alanine; F is Ser, hSer, Lys, Leu, Val, Nle, Ile, D-Ser, D-Gln, or Thr; F' is Arg; P is D-Phe which is optionally substituted by fluorine, chlorine, bromine or methoxy; K is a direct bond; M is a direct bond; and I is --OH, --NH.sub.2 or --NHC.sub.2 H.sub.5. 19. A peptide of the formula I or salt as claimed in claim 15 in which A is hydrogen, (D)- or (L)-H-Arg, (D)- or (L)-H-Lys or (D)- or (L)-H-Orn; B is Arg, Orn or Lys, wherein the guanidino group or the amino group of the side chain is optionally substituted by (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, wherein the aryloyl, arylsulfonyl and heteroaryloyl radicals are optionally substituted with 1, 2, 3 or 4 identical or different radicals selected from the group consisting of methyl, methoxy and halogen; C is Pro-Pro-Gly, Hyp-Pro-Gly or Pro-Hyp-Gly; E is Phe or Thia; F is Ser; K is a direct bond; M is a direct bond; G is Oic; F' is Arg; and I is OH. 20. A peptide of the formula I or salt as claimed in claim 19, in which G is a heterocyclic radical selected from octahydroindole (E), octahydrocyclopenta[b]pyrrole (F), decahydrocyclohepta[b]pyrrole (N), octahydroisoindole (O), and decahydroisoquinoline (D). 21. A peptide of the formula H-(D)-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-(D)-Phe-Oic-Arg-OH or a physiologically tolerable salt of said peptide. 22. A peptide of the formula H-(D)-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-(D)-Phe-Oic-Arg-OH or a physiologically tolerable salt of said peptide. 23. A peptide of the formula H-(D)-Arg-Arg-Pro-Pro-Gly-Phe-Ser-(D)-(p-Cl)Phe-Oic-Arg-OH or a physiologically tolerable salt of said peptide. 24. A peptide of the formula H-(D)-Arg-Arg-Pro-Hyp-Gly-Tbg-Ser-(D)-Tic-Oic-Arg-OH or a physiologically tolerable salt of said peptide. 25. A method for the treatment of a pathological state which is mediated, caused or supported by bradykinin and bradykinin-related peptides in a patient, wherein said pathological state is selected from the group consisting of wounds, burns, rashes, erythemas, edemas, angina, arthritis, asthma, allergies, rhinitis, shock, inflammations, low blood pressure, pain, itching, and changed sperm motility, wherein said method comprises administering to said patient an effective amount of the peptide as claimed in claim 1 or a physiologically tolerated salt of said peptide. 26. A method of treating asthma in a human comprising administering to said human an effective amount of the peptide as claimed in claim 1, or a physiologically tolerated salt of said peptide. 27. A pharmaceutical composition for the treatment of a pathological state which is mediated, caused or supported by bradykinin and bradykin-related peptides, wherein said pathological state is selected from the group consisting of wounds, burns, rashes, erythemas, edemas, angina, arthritis, asthma, allergies, rhinitis, shock, inflammations, low blood pressure, pain, itching, and changed sperm motility, wherein said pharmaceutical composition comprises an effective amount of the peptide as claimed in claim 1 or a physiologically tolerated salt of said peptide, and a pharmaceutically acceptable vehicle. 28. A method for the treatment of a pathological state which is mediated, caused or supported by bradykinin and bradykinin-related peptides in a patient, wherein said pathological state is selected from the group consisting of wounds, burns, rashes, erythemas, edemas, angina, arthritis, asthma, allergies, rhinitis, shock, inflammations, low brood pressure, pain, itching, and changed sperm motility, wherein said method comprises administering to said patient an effective amount of the peptide as claimed in claim 15, or a physiologically tolerated salt of said peptide. 29. A method of treating asthma in a human comprising administering to said human an effective amount of the peptide as claimed in claim 15, or a physiologically tolerated salt of said peptide. 30. A pharmaceutical composition for the treatment of a pathological state which mediated, caused or supported by bradykinin and bradykinin-related peptides, wherein said pathological state is selected from the group consisting of wounds, burns, rashes, erythemas, edemas, angina, arthritis, asthma, allergies, rhinitis, shock, inflammations, low blood pressure, pain, itching, and changed sperm motility, wherein said pharmaceutical composition comprises an effective amount of the peptide as claimed in claim 15 or a physiologically tolerated salt of said peptide, and a pharmaceutically acceptable vehicle. 31. A method for the treatment of a pathological state which is mediated, caused or supported by bradykinin and bradykinin-related peptides in a patient, wherein said pathological state is selected from the group consisting of wounds, burns, rashes, erythemas, edemas, tonsillitis, arthritis, asthma, allergies, rhinitis, shock, inflammations, low blood pressure, pain, pruritis, and changed sperm motility, wherein said method comprises administering to said patient an effective amount of the peptide as claimed in claim 24, or a physiologically tolerated salt of said peptide. 32. A method of treating asthma in a human comprising administering to said human an effective amount of the peptide as claimed in claim 24, or a physiologically tolerated salt of said peptide. 33. A pharmaceutical composition for the treatment of a pathological state which is mediated, caused or supported by bradykinin and bradykinin-related peptides, wherein said pathological state is selected from the group consisting of wounds, burns, rashes, erythemas, edemas, tonsillitis, arthritis, asthma, allergies, rhinitis, shock, inflammations, low blood pressure, pain, pruritis, and changed sperm motility, wherein said pharmaceutical composition comprises an effective amount of the peptide as claimed in claim 24 or a physiologically tolerated salt of said peptide, and a pharmaceutically acceptable vehicle. -------------------------------------------------------------------------------- |
| PATENT DESCRIPTION |
SUMMARY AND DETAILED DESCRIPTION OF THE INVENTION The present invention relates to novel peptides having bradykinin antagonist action and to a process for their preparation. Bradykinin antagonist peptides are described in WO 86/07263 in which, inter alia, L-Pro in position 7 of the peptide hormone bradykinin or other bradykinin analogs is replaced by a D-amino acid, such as D-Phe, D-Thi, D-Pal, CDF, D-Nal, MDY, D-Phg, D-His, D-Trp, D-Tyr, D-hPhe, D-Val, D-Ala, D-His, D-Ile, D-Leu and DOMT. The present invention is based on the object of finding novel active peptides having bradykinin antagonist action. This object is achieved by the peptides of the formula I A-B-C-E-F-K-P-G-M-F'-I (I), in which A a.sub.1) denotes hydrogen, (C.sub.1 -C.sub.8)-alkyl, (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.1 -C.sub.8)-alkoxycarbonyl or (C.sub.1 -C.sub.8)-alkylsulfonyl, in which in each case 1, 2 or 3 hydrogen atoms are optionally replaced by 1, 2 or 3 identical or different radicals from the series comprising carboxyl, amino, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl, (C.sub.1 -C.sub.4)-alkoxycarbonyl, (C.sub.6 -C.sub.12)-aryl and (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.5)-alkyl, or in which in each case 1 hydrogen atom is optionally replaced by a radical from the series comprising (C.sub.3 -C.sub.8)-cycloalkyl, (C.sub.1 -C.sub.4)-alkylsulfonyl, (C.sub.1 -C.sub.4)-alkylsulfinyl, (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.4)-alkylsulfonyl (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.4)-alkylsulfinyl, (C.sub.6 -C.sub.12)-aryloxy, (C.sub.3 -C.sub.9)-heteroaryl and (C.sub.3 -C.sub.9)-heteroaryloxy and 1 or 2 hydrogen atoms are replaced by 1 or 2 identical or different radicals from the series comprising carboxyl, amino, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl, (C.sub.1 -C.sub.4)-alkoxycarbonyl, (C.sub.6 -C.sub.12)-aryl and (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.5)-alkyl, a.sub.2) denotes (C.sub.3 -C.sub.8)-cycloalkyl, carbamoyl, which may be optionally substituted on the nitrogen by (C.sub.1 -C.sub.6)-alkyl or (C.sub.6 -C.sub.12)-aryl, (C.sub.6 -C.sub.12)-aryl, (C.sub.7 -C.sub.18)-aryloyl, (C.sub.6 -C.sub.12)-arylsulfonyl, (C.sub.3 -C.sub.9)-heteroaryl, or (C.sub.3 -C.sub.9)-heteroaryloyl, where in the radicals defined under a.sub.1) and a.sub.2) in each case aryl, heteroaryl, aryloyl, arylsulfonyl and heteroaryloyl is optionally substituted by 1, 2, 3 or 4 identical or different radicals from the series comprising carboxyl, amino, nitro, (C.sub.1 -C.sub.4)-alkylamino, hydroxyl, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy, halogen, cyano, di-(C.sub.1 -C.sub.4)-alkylamino, carbamoyl, sulfamoyl and (C.sub.1 -C.sub.4)-alkoxycarbonyl, or a.sub.3) denotes a radical of the formula II ##STR1## R.sup.1 is defined as A under a.sub.1) or a.sub.2), R.sup.2 denotes hydrogen or methyl, R.sup.3 denotes hydrogen or (C.sub.1 -C.sub.6)-alkyl, preferably (C.sub.1 -C.sub.4)-alkyl, which is optionally monosubstituted by amino, substituted amino, hydroxyl, carboxyl, carbamoyl, guanidino, substituted guanidino, ureido, mercapto, methylmercapto, phenyl, 4-chlorophenyl, 4-fluorophenyl, 4-nitrophenyl, 4-methoxyphenyl, 4-hydroxyphenyl, phthalimido, 4-imidazolyl, 3-indolyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl or cyclohexyl, where substituted amino stands for a compound --NH--A-- and substituted guanidino stands for a compound --NH--C(NH)--NH--A, in which A is defined as under a.sub.1) or a.sub.2); B stands for a basic amino acid in the L- or D-configuration, which may be substituted in the side chain; C stands for a compound of the formula IIIa or IIIb ______________________________________ G'-G'-Gly G'-NH--(CH.sub.2).sub.n --CO (Illa) (IIIB) ______________________________________ in which G' independently of one another denotes a radical of the formula IV ##STR2## in which R.sup.4 and R.sup.5 together with the atoms carrying them form a heterocyclic mono-, bi- or tricyclic ring system having 2 to 15 carbon atoms, and n is 2 to 8; E is a radical of an aromatic amino acid or is the residue of a neutral, acidic or basic aliphatic or alicyclic-aliphatic amino acid; F independently of one another denotes the radical of a neutral, acidic or basic, aliphatic or aromatic amino acid which may be substituted in the side chain, or stands for a direct bond; P denotes a radical of the formula V ((D)-Tic) ##STR3## or D-phenylalanine ((D)-Phe) which may be optionally substituted in the phenyl moiety; G is as defined above for G' or denotes a direct bond; F' is as defined for F, denotes a radical --NH--(CH.sub.2).sub.n --, with n=2 to 8, or, if G does not denote a direct bond, can stand for a direct bond, I is --OH, --NH.sub.2 or --NHC.sub.2 H.sub.5, K denotes the radical --NH--(CH.sub.2).sub.x --CO-- with x=1-4 or stands for a direct bond, and M is as defined for F, and their physiologically tolerable salts. If not stated otherwise, the abbreviation of an amino acid radical without a stereodescriptor stands for the radical in the L-form (compare Schroder, Lubke, The Peptides, Volume I, New York 1965, pages XXII-XXIII; Houben-Weyl, Methoden der Organischen Chemie (Methods of Organic Chemistry), Volume XV/1 and 2, Stuttgart 1974), such as, for example, Aad, Abu, .gamma.Abu, ABz, 2ABz, .epsilon.Aca, Ach, Acp, Adpd, Ahb, Aib, .beta.Aib, Ala, .beta.Ala, .DELTA.Ala, Alg, All, Ama, Amt, Ape, Apm, Apr, Arg, Asn, Asp, Asu, Aze, Azi, Bai, Bph, Can, Cit, Cys, Cyta, Daad, Dab, Dadd, Dap, Dapm, Dasu, Djen, Dpa, Dtc, Fel, Gln, Glu, Gly, Guv, hAla, hArg, hCys, hGln, hGlu, His, hIle, hLeu, hLys, hMet, hPhe, hPro, hSer, hThr, hTrp, hTyr, Hyl, Hyp, 3Hyp, Ile, Ise, Iva, Kyn, Lant, Lcn, Leu, Lsg, Lys, .beta.Lys, .DELTA.Lys, Met, Mim, Min, nArg, Nle, Nva, Oly, Orn, Pan, Pec, Pen, Phe, Phg, Pic, Pro, .DELTA.Pro, Pse, Pya, Pyr, Pza, Qin, Ros, Sar, Sec, Sem, Ser, Thi, .beta.Thi, Thr, Thy, Thx, Tia, Tle, Tly, Trp, Trta, Tyr, Val. When E is a radical of an aromatic amino acid and P is D-Tic, suitable radicals of a heterocyclic ring system of the formula IV are preferably radicals of heterocycles of the group below: pyrrolidine (A); piperidine (B); tetrahydroisoquinoline (C); decahydroisoquinoline (D); octahydroindole (E); octahydrocyclopenta[b]pyrrole (F); 2-aza-bicyclo[2.2.2]octane (G); 2-azabicyclo[2.2.1]heptane (H); 2-azaspiro[4.5]decane (I), 2-azaspiro[4.4]nonane (J); spiro[(bicyclo[2.2.1]heptane)-2,3-pyrrolidine] (K); spiro[(bicyclo[2.2.2]octane)-2,3-pyrrolidine] (L); 2-azatricyclo-[4.3.0.1.sup.6,9 ]decane (M); decahydrocyclohepta[b]pyrrole (N); 6octahydroisoindole (O); octahydrocyclopenta[c]pyrrole (P); 2,3,3a,4,5,7a-hexahydroindole (Q); tetrahydrothiazole (R); 2-azabicyclo[3.1.0]hexane (S); isoxazolidine (T); pyrazolidine (U); and hydroxyproline (V); all of which may be optionally substituted. These radicals are shown below: ##STR4## When (1) E is a radical of an aromatic amino acid and P is (D)-Phe, which is optionally substituted in the phenyl moiety or (2) E is the residue of a neutral, acidic or basic aliphatic or alicyclic-aliphatic amino acid and P is D-Tic, suitable radicals of a heterocyclic ring system of the formula IV are preferably radicals of heterocycles of the group below: pyrrolidine-2-carboxylic acid; piperidine-2-carboxylic acid; 1,2,3,4,-tetrahydroisoquinoline-3-carboxylic acid; decahydroisoquinoline-3-carboxylic acid; octahydroindole-2-carboxylic acid; decahydroquinoline-2-carboxylic acid; octahydrocyclopenta[b]pyrrole-2-carboxylic acid; 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid; 2-azabicyclo[2.2.1]heptane-3-carboxylic acid; 2-azabicyclo[3.1.0]hexane-3-carboxylic acid; 2-azaspiro[4.4]nonane-3-carboxylic acid; 2-azaspiro[4.5]-decane-3-carboxylic acid; spiro[(bicyclo[2.2.1]-heptane)-2,3-pyrrolidine-5-carboxylic acid]; spiro[(bicyclo[2.2.2]octane)-2,3-pyrrolidine-5-carboxylic acid]; 2-azatricyclo[4.3.0.1.sup.6,9 ]decane-3-carboxylic acid; decahydrocyclohepta[b]pyrrole-2-carboxylic acid; decahydrocycloocta[b]pyrrole-2-carboxylic acid; octahydrocyclotenta[c]pyrrole-2-carboxylic acid; octahydroisoindole-1-carboxylic acid; 2,3,3a,4,6a-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid; 2,3,3a,4,5,7a-hexahydroindole-2-carboxylic acid; tetrahydrothiazole-4-carboxylic acid; isoxalidine-3-carboxylic acid; pyrazolidine-3-carboxylic acid; and hydroxyproline-2-carboxylic acid; all of which may be optionally substituted. These radicals are shown below: ##STR5## The heterocycles based on the above mentioned radicals are known, for example, from U.S. Pat. Nos. 4,344,949, 4,374,847, 4,350,704, EP-A-50,800, EP-A-31,741, EP-A-51,020, EP-A-49,658, EP-A-49,605, EP-A-29,488, EP-A-46,953, EP-A-52,870, EP-A-271,865, DE-A-3,226,768, DE-A-3,151,690, DE-A-3,210,496, DE-A-3,211,397, DE-A-3,211,676, DE-A-3,227,055, DE-A-3,242,151, DE-A-3,246,503 and DE-A-3,246,757. Some of these heterocycles are furthermore proposed in DE-A-3,818,850.3. If not stated otherwise in the individual case, alkyl can be straight chain or branched. The same applies to radicals derived therefrom, such as alkoxy, aralkyl or alkanoyl. (C.sub.6 -C.sub.12)-Aryl preferably denotes phenyl, naphthyl or biphenylyl. Radicals derived therefrom, such as aryloxy, aralkyl or aroyl, are to be formulated correspondingly. Halo stands for fluorine, chlorine, bromine or iodine, preferably for chlorine. Preferred salts are alkali metal or alkaline earth metal salts, salts with physiologically tolerable amines and salts with inorganic or organic acids such as, for example, HCl, HBr, H.sub.2 SO.sub.4, H.sub.3 PO.sub.4, maleic acid, fumaric acid, citric acid, tartaric acid and acetic acid. Preferred peptides of the formula I are those in which 1. E is a radical of an aromatic amino acid; and P is D-Tic; 2. E is a radical of an aromatic amino acid; and P is (D)-Phe which may be optionally substituted in the phenyl moiety; and E is the residue of a neutral, acidic or basic aliphatic or alicyclic-aliphatic amino acid; and P is D-Tic. More preferred peptides of the formula I are those in which 1. B denotes Arg, Lys, Orn, 2,4-diaminobutyroyl or an L-homoarginine radical, where in each case the amino or guanidino group of the side chain may be substituted by as described under a.sub.1) or a.sub.2); E stands for the radical of an aromatic amino acid in the L- or D-configuration, which contains 6 to 14 carbon atoms in the aryl moiety as ring members, such as phenylalanine which is optionally substituted by halogen in the 2-, 3- or 4-position, tyrosine, O-methyltyrosine, 2-thienylalanine, 2-pyridylalanine or naphthylalanine; P denotes D-Tic; F' denotes the radical of a basic amino acid in the L- or D-configuration, such as Arg or Lys, where the guanidino --NH--(CH.sub.2).sub.n -- with n=2 to 8; and K group or amino group of the side chain may be replaced by A as described under a.sub.1) or a.sub.2), or denotes a radical K stands for the radical --NH--(CH.sub.2).sub.x --CO-- with x=2-4 or denotes a direct bond; 2. B denotes Arg, Lys, Orn, 2,4-diaminobutyroyl or an L-homoarginine radical, where in each case the amino or guanidino group of the side chain may be substituted by A as described under a.sub.1) or a.sub.2); E stands for the radical of an aromatic amino acid in the L- or D-configuration, which contains 6 to 14 carbon atoms in the aryl moiety as ring members, such as phenylalanine which is optionally substituted by halogen in the 2-, 3- or 4-position, tyrosine, O-methyltyrosine, 2-thienylalanine, 2-pyridylalanine or naphthylalanine; P is D-Phe which may be optionally substituted in the phenyl moiety by halogen or (C.sub.1 -C.sub.4)-alkoxy; F' denotes the radical of a basic amino acid in the L- or D-configuration, such as Arg or Lys, where the guanidino group or amino group of the side chain may be replaced by A as described under a.sub.1) or a.sub.2), or denotes a radical --NH--(CH.sub.2).sub.n -- with n=2 to 8; and K stands for the radical --NH--(CH.sub.2).sub.x --CO-- with x=2-4 or denotes a direct bond; and 3. B denotes Arg, Lys, Orn, 2,4-diaminobutyroyl or an L-homoarginine radical, where in each case the amino or guanidino group of the side chain may be substituted by A as described under a.sub.1) or a.sub.2); E is the residue of an aliphatic or alicyclic-aliphatic amino acid which is in the L or D configuration and which contains 1 to 14 carbon atoms in the side chain, such as alanine, serine, threonine, O-(C.sub.1 -C.sub.6)-alkyl- or O-(C.sub.6 -C.sub.10)-aryl-protected serine or threonine, valine, norvaline, leucine, isoleucine, norleucine, neopentylglycine, tert-butylglycine or (C.sub.3 -C.sub.7)-cycloalkyl-(C.sub.1 -C.sub.3)-alkylglycine; P denotes D-Tic; F' denotes the radical of a basic amino acid in the L- or D-configuration, such as Arg or Lys, where the guanidino group or amino group of the side chain may be replaced by A as described under a.sub.1) or a.sub.2), or denotes a radical --NH--(CH.sub.2).sub.n -- with n=2 to 8; and K stands for the radical --NH--(CH.sub.2).sub.x --CO-- with x=2-4 or denotes a direct bond. Even more preferred peptides of the formula I are those in which 1. B denotes Arg, Orn or Lys, where the guanidino group or the amino group of the side chain is unsubstituted or may be substituted by (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, where the aryl, heteroaryl, aryloyl, arylsulfonyl and heteroaryloyl radicals may optionally be substituted, as described under a.sub.2), with 1, 2, 3 or 4 identical or different radicals; E denotes phenylalanine, 2-chlorophenylalanine, 3-chlorophenylalanine, 4-chlorophenylalanine, 2-fluorophenylalanine, 3-fluorophenylalanine, 4-fluorophenylalanine, tyrosine, O-methyltyrosine or .beta.-(2-thienyl)alanine; P denotes D-Tic; K stands for a direct bond; and M stands for a direct bond; B denotes Arg, Orn or Lys, where the guanidino group or the amino group of the side chain is unsubstituted or may be substituted by (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, where the aryl, heteroaryl, aryloyl, arylsulfonyl and heteroaryloyl radicals may optionally be substituted, as described under a.sub.2), with 1, 2, 3 or 4 identical or different radicals; E denotes phenylalanine, 2-chlorophenylalanine, 3-chlorophenylalanine, 4-chlorophenylalanine, 2-fluorophenylalanine, 3-fluorophenylalanine, 4-fluorophenylalanine, tyrosine, O-methyltyrosine or .sup..beta. -(2-thienyl)alanine; P denotes D-Phe which may be optionally substituted by fluorine, chlorine, bromine or methoxy; K stands for a direct bond; and M stands for a direct bond; and 3. B denotes Arg, Orn or Lys, where the guanidino group or the amino group of the side chain is unsubstituted or may be substituted by (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, where the aryl, heteroaryl, aryloyl, arylsulfonyl and heteroaryloyl radicals may optionally be substituted, as described under a.sub.2), with 1, 2, 3 or 4 identical or different radicals. E denotes leucine, isoleucine, norleucine, tert-butylglycine, serine, threonine or cyclohexylalanine; P denotes D-Tic; K stands for a direct bond; and M stands for a direct bond. Still even more preferred peptides of the formula I are those in which 1. A denotes hydrogen, (D)- or (L)-H-Arg, (D)- or (L)-H-Lys or (D)- or (L)-H-Orn; B denotes Arg, Orn or Lys, where the guanidino group or the amino group of the side chain may be substituted by hydrogen, (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, where the aryl, heteroaryl, aryloyl, arylsulfonyl and heteroaryloyl radicals may optionally be substituted with 1, 2, 3 or 4 identical or different radicals from the series comprising methyl, methoxy and halogen; C denotes Pro-Pro-Gly, Hyp-Pro-Gly or Pro-Hyp-Gly; E denotes Phe or Thia; F denotes Ser, hSer, Lys, Leu, Val, Nle, Ile or Thr; P denotes D-Tic; K stands for a direct bond; M stands for a direct bond; G stands for the radical of a heterocyclic ring system of the formula IV, where the radicals of the heterocycles pyrrolidine (A); piperidine (B); tetrahydroisoquinoline (C); cis- and trans-decahydroisoquinoline (D); cis-endo-octahydroindole (E), cis-exo-octahydroindole (E), trans-octahydroindole (E), cis-endo-, cis-exo-, trans-octahydrocyclopentano[b]pyrrole (F), or hydroxyproline (V) are preferred; F' denotes Arg; and I stands for OH; 2. A denotes hydrogen, (D)- or (L)-H-Arg, (D)- or (L)-H-Lys or (D)- or (L)-H-Orn; B denotes Arg, Orn or Lys, where the guanidino group or the amino group of the side chain may be substituted by hydrogen, (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, where the aryl, heteroaryl, aryloyl, arylsulfonyl and heteroaryloyl radicals may optionally be substituted with 1, 2, 3 or 4 identical or different radicals from the series comprising methyl, methoxy and halogen; C denotes Pro-Pro-Gly, Hyp-Pro-Gly or Pro-Hyp-Gly; E denotes Phe or Thia; F denotes Ser, hSer, Lys, Leu, Val, Nle, Ile or Thr; P denotes (D)-Phe which may be optionally substituted in the phenyl moiety; K stands for a direct bond; M stands for a direct bond; G stands for the radical of a heterocyclic ring system of the formula IV, where the radicals of the heterocycles pyrrolidine-2-carboxylic acid; piperidine-2-carboxylic acid; 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, cis- and trans-decahydroisoquinoline-3-carboxylic acid; cis-endo-,cis-exo-,trans-octahydroindole-2-carboxylic acid, cis-endo-, cis-exo-, trans-octahydrocyclopentano[b]pyrrole-2-carboxylic acid or hydroxyproline-2-carboxylic acid are preferred; F' denotes Arg; and I stands for OH; and A denotes hydrogen, (D)- or (L)-H-Arg, (D)- or (L)-H-Lys or (D)- or (L)-H-Orn; B denotes Arg, Orn or Lys, where the guanidino group or the amino group of the side chain may be substituted by hydrogen, (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.7 -C.sub.13)-aryloyl, (C.sub.3 -C.sub.9)-heteroaryloyl, (C.sub.1 -C.sub.8)-alkylsulfonyl or (C.sub.6 -C.sub.12)-arylsulfonyl, where the aryl, heteroaryl, aryloyl, arylsulfonyl and heteroaryloyl radicals may optionally be substituted with 1, 2, 3 or 4 identical or different radicals from the series comprising methyl, methoxy and halogen; C denotes Pro-Pro-Gly, Hyp-Pro-Gly or Pro-Hyp-Gly; E denotes Leu, Ile, Tbg or Cha; F denotes Ser, hSer, Lys, Leu, Val, Nle, Ile or Thr; P denotes D-Tic; K stands for a direct bond; M stands for a direct bond; G stands for the radical of a heterocyclic ring system of the formula IV, where the radicals of the heterocycles pyrrolidine-2-carboxylic acid; piperidine-2-carboxylic acid; 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, cis- and trans-decahydroisoquinoline-3-carboxylic acid; cis-endo-,cis-exo-,trans-octahydroindole-2-carboxylic acid, cis-endo-, cis-exo-, trans-octahydrocyclopentano[b]pyrrole-2-carboxylic acid or hydroxyproline-2-carboxylic acid are preferred; F' denotes Arg; and I stands for OH. Examples of very particularly preferred peptides of the formula I are: H-D-Arg-Arg-Hyp-Pro-Gly-Phe-Ser-D-Tic-Oic-Arg-OH; H-D-Arg-Arg-Pro-Pro-Gly-Phe-Ser-D-Tic-Oic-Arg-OH; H-D-Arg-Arg-Hyp-Pro-Gly-Thia-Ser-D-Tic-Aoc-Arg-OH; H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Aoc-Arg-OH; H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Tic-Arg-OH; H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Oic-Arg-OH; H-D-Arg-Arg-Pro-Pro-Gly-Thia-Ser-D-Tic-Oic -Arg-OH; H-D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Tic-Oic-Arg-OH; H-D-Arg-Arg(NO.sub.2 )-Pro-Hyp-Gly-Phe-Ser-D-Tic-Aoc-Arg-OH; H-Arg(Tos)-Pro-Hyp-Gly-Thia-Ser-D-Tic-Oic-Arg-OH; H-(D)-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-(D)-Phe-Oic-Arg-OH; H-(D)-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-(D)-Phe-Oic-Arg-OH; H-(D)-Arg-Arg-Pro-Pro-Gly-Phe-Ser-(D)-(p-Cl)Phe-Oic-Arg-OH; H-(D)-Arg-Arg-Pro-Hyp-Gly-Leu-Ser-(D)-Tic-Oic-Arg-OH; H-(D)-Arg-Arg-Pro-Hyp-Gly-Cha-Ser-(D)-Tic-Oic-Arg-OH; or H-(D)-Arg-Arg-Pro-Hyp-Gly-Tbg-Ser-(D)-Tic-Oic-Arg-OH. The most preferred peptide of the formula I is H-D-Arg-Arg-Pro-Hyp-Gly-Thia-Ser-D-Tic-Oic-Arg-OH. The invention furthermore relates to a process for the preparation of peptides of the formula I, which comprises a) reacting a fragment having a C-terminal free carboxyl group or its activated derivative with an appropriate fragment having an N-terminal free amino group or b) synthesizing the peptide stepwise, optionally splitting off one or more protective groups temporarily introduced for the protection of other functions in the compound obtained according to (a) or (b) and optionally converting the compounds of the formula I thus obtained into their physiologically tolerable salt. The peptides of the present invention were prepared by generally known methods of peptide chemistry, see, for example, Houben-Weyl, Methoden der organischen Chemie (Methods of Organic Chemistry), Volume 15/2, and preferably by means of solid phase synthesis such as described, for example, by B. Merrifield, J. Am. Chem. Soc. 85, 2149 (1963) or R. C. Sheppard, Int. J. Peptide Protein Res. 21, 118 (1983) or by equivalent known methods. Urethane protective groups such as, for example, the tert-butyloxy-carbonyl (Boc) or fluorenylmethoxycarbonyl (Fmoc) protective group are used as .alpha.-amino protective group. If necessary for the prevention of side reactions or for the synthesis of specific peptides, the functional groups in the side chain of amino acids are additionally protected by suitable protective groups (see, for example, T. W. Greene, "Protective Groups in Organic Synthesis"), where primarily, Arg(Tos), Arg(Mts), Arg(Mtr), Arg(PMC), Asp(OBzl), Asp(OBut), Cys(4-MeBzl), Cys(Acm), Cys(SBut), Glu(OBzl), Glu(OBut), His(Tos), His(Fmoc), His(Dnp), His(Trt), Lys(Cl-Z), Lys(Boc), Met(O), Ser(Bzl), Ser(But), Thr(Bzl), Thr(But), Trp(Mts), Trp(CHO), Tyr(Br-Z), Tyr(Bzl) or Tyr(But) are employed. Solid phase synthesis begins at the C-terminal end of the peptide with the coupling of a protected amino acid to an appropriate resin. Starting materials of this type may be obtained by linking a protected amino acid via an ester or amide bond to a polystyrene or polyacrylamide resin modified with a chloromethyl, hydroxymethyl, benzhydryl-amino(BHA) or methylbenzhydrylamino (MBHA) group. The resins used as support materials are commercially obtainable. BHA and MBHA resins are usually used if the peptide synthesized is intended to have a free amide group at the C-terminus. If the peptide is intended to have a secondary amide group at the C-terminal end, a chloromethyl or hydroxymethyl resin is used and the splitting off is carried out using the corresponding amines. If it is wished to obtain, for example, the ethylamide, the peptide can be split off from the resin using ethylamine, the splitting off of the side chain protective groups subsequently being carried out by means of other suitable reagents. If it is intended to retain the tert-butyl protective groups of the amino acid side chain in the peptide, the synthesis is carried out using the Fmoc protective group for temporary blocking of the .alpha.-amino group of the amino acid using the method described, for example, in R. C. Sheppard, J. Chem. Soc., Chem. Comm 1982, 587, the guanidino function of the arginine being protected by protonation with pyridinium perchlorate and the protection of the other functionalized amino acids in the side chain being carried out using benzyl protective groups which can be split off by means of catalytic transfer hydrogenation (A. Felix et al., J. Org. Chem. 13, 4194 (1978)) or by means of sodium in liquid ammonia (W. Roberts, J. Am. Chem. Soc. 76, 6203 (1954)). After splitting off the amino protective group of the amino acid coupled to the resin using a suitable reagent, such as, for example, trifluoroacetic acid in methylene chloride in the case of the Boc protective group or a 20% strength solution of piperidine in dimethylformamide in the case of the Fmoc protective group, the subsequently protected amino acids are successively coupled in the desired sequence. The intermediately resulting N-terminal protected peptide resins are deblocked by means of the reagents described above before linkage with the subsequent amino acid derivative. All possible activating reagents used in peptide synthesis can be used as coupling reagents, see, for example, Houben-Weyl, Methoden der organischen Chemie (Methods of Organic Chemistry), Volume 15/2, in particular, however, carbodiimides such as, example, N,N'-dicyclohexylcarbodiimide, N,N'-diisopropylcarbodiimide or N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide. The coupling can in this case be carried out directly by addition of amino acid derivative and the activating reagent and, if desired, a racemization-suppressing additive such as, for example, 1-hydroxy-benzotriazole (HOBt) (W. Konig, R. Geiger, Chem. Ber. 103, 708 (1970)) or 3-hydroxy-4-oxo-3,4-dihydrobenzo-triazine (HOObt) (W. Konig, R. Geiger, Chem. Ber. 193, 2054 (1970)) to the resin or, however, the preactivation of the amino acid derivative as symmetrical anhydride or HOBt or HOObt ester can be carried out separately and the solution of the activated species in a suitable solvent can be added to the peptide resin capable of coupling. The coupling or activation of the amino acid derivative with one of the above mentioned activating reagents can be carried out in dimethylformamide, N-methylpyrrolidone or methylene chloride or a mixture of the solvents mentioned. The activated amino acid derivative is customarily employed in a 1.5 to 4 fold excess. In cases in which an incomplete coupling takes place, the coupling reaction is repeated without previously carrying out the deblocking of the .alpha.-amino group of the peptide resin necessary for the coupling of the following amino acid. The successful course of the coupling reaction can be monitored by means of the ninhydrin reaction, such as described, for example, by E. Kaiser et al., Anal. Biochem. 34, 595 (1970). The synthesis can also be automated, for example using a peptide synthesizer model 430A from Applied Biosystems, it being possible either to use the synthesis program provided by the apparatus manufacturer or else, however, one set up by the user himself. The latter are in particular employed in the use of amino acid derivatives protected with the Fmoc group. After synthesis of the peptides in the previously described manner, the peptide can be split off from the resin using reagents, such as, for example, liquid hydrogen fluoride (preferably in the peptides prepared according to the Boc method) or trifluoroacetic acid (preferably in the peptides synthesized according to the Fmoc method). These reagents not only cleave the peptide from the resin but also the other side chain protective groups of the amino acid derivative. In this manner, the peptide is obtained in the form of the free acid in addition using BHA and MBHA resins. With the BHA or MBHA resins, the peptide is obtained as acid amide when splitting off is carried out using hydrogen fluoride or trifluoromethanesulfonic acid. Additional processes for the preparation of peptide amides are described in German Patent Application Nos. P 37 11 866.8 and P 37 43 620.1 and Europe Patent Applications Nos. 271,865, 287,882 and 322,348. The splitting off of the peptide amides from the resin here is carried out by treatment with medium strength acids (for example trifluoroacetic acid) usually used in peptide synthesis, cation entrainer substances such as phenol, cresol, thiocresol, anisole, thioanisole, ethanedithiol, dimethyl sulfide, ethyl methyl sulfide or similar cation entrainers customary in solid phase synthesis being added individually or as a mixture of two or more of these auxiliaries. In this case, the trifluoroacetic acid can also be used diluted by suitable solvents, such as, for example, methylene chloride. If the tert-butyl or benzyl side chain protective groups of the peptides are to be retained, the splitting off of the peptide synthesized on a particularly modified support resin is carried out using 1% trifluoroacetic acid in methylene chloride, such as described, for example, in R. C. Sheppard, J. Chem. Soc., Chem. Comm. 1982, 587. If individual tert-butyl or benzyl side chain protective groups are to be retained, a suitable combination of synthesis and splitting off methods is used. For the synthesis of peptides having a C-terminal amide grouping or an .omega.-amino or .omega.-guanidinoalkyl grouping, the modified support resin described by Sheppard is likewise used. After the synthesis, the peptide fully protected in the side chain is split off from the resin and subsequently reacted with the appropriate amine or .omega.-aminoalkylamine or .omega.-guanidinoalkylamine in classical solution synthesis, it being possible for optionally present additional functional groups to be temporarily protected in a known manner. An additional process for the preparation of peptides having an .omega.-aminoalkyl grouping is described in German Patent Application P 36 35 670.0 and European Patent Application 264,802. The peptides of the present invention were preferably synthesized by two general protective group tactics using the solid phase technique: The synthesis was carried out using an automatic peptide synthesizer model 430 A from Applied Biosystems, with Boc or Fmoc protective groups for temporary blockage of the .alpha.-amino group. When using the Boc protective group, the synthesis cycles pre-programmed by the manufacturer of the apparatus were used for the synthesis. The synthesis of the peptides having a free carboxyl group on the C-terminal end was carried out on a 4-(hydroxymethyl)phenylacetamidomethylpolystyrene resin functionalized with the corresponding Boc amino acid (R. B. Merrifield, J. Org. Chem. 43, 2845 (1978)) from Applied Biosystems. An MBHA resin from the same firm was used for the preparation of the peptide amides. N,N'-dicyclohexylcarbodiimide or N,N'-diisopropylcarbodiimide were used as activating reagents. Activation was carried out as the symmetrical anhydride, as the HOBt ester or HOObt ester in CH.sub.2 Cl.sub.2, CH.sub.2 C.sub.12 -DMF mixtures or NMP. 2-4 equivalents of activated amino acid derivative were employed for the coupling. In cases in which the coupling took place incompletely, the reaction was repeated. During the use of the Fmoc protective group for the temporary protection of the .alpha.-amimo group, our own synthesis programs were used for synthesis using the automatic peptide synthesizer model 430A from Applied Biosystems. The synthesis was carried out on a p-benzyloxybenzyl alcohol resin (S. Wang, J. Am. Chem. Soc. 95, 1328 (1973)) from Bachem which was esterified by a known method (E. Atherton et al., J.C.S. Chem. Comm. 1981, 336) using the appropriate amino acid. The activation of the amino acid derivatives as HOBt or HOObt esters was carried out directly in the amino acid cartridges provided by the apparatus manufacturer by addition of a solution of diisopropylcarbodiimide in previously weighed-in mixture of amino acid derivative and HOBt or HOObt. Fmoc-amino acid-OObt esters prepared in substance can likewise be employed as described in European Patent Application No. 247,573. The splitting off of the Fmoc protective group was carried out using a 20% strength solution of piperidine in DMF in the reaction vessel. The excess of reactive amino acid derivative used was 1.5 to 2.5 equivalents. If the coupling was not complete, it was repeated as in the Boc method. The peptides according to the invention have, individually or in combination, a bradykinin antagonist action which can be tested in various models (see Handbook of Exp. Pharmacol. Vol. 25, Springer Verlag, 1970, p. 53-55), for example on the isolated rat uterus, on the guinea pig ileum or on the isolated pulmonary artery of the guinea pig. For testing the peptides according to the invention on the isolated arteria pulmonalis, guinea pigs (Dunkin Hartley) having a weight of 400-450 g are sacrificed by a blow to the back of the neck. The thorax is opened and the arteria pulmonalis is carefully dissected out. The surrounding tissue is carefully removed and the arteria pulmonalis is cut spirally at an angle of 45.degree.. The vessel strip of 2.5 cm length and 3-4 mm width is fixed in a 10 ml capacity organ bath which is filled with Ringer solution. ______________________________________ Composition of the solution in mmol/l ______________________________________ NaCl 154 KCl 5.6 CaCl.sub.2 1.9 NaHCO.sub.3 2.4 Glucose 5.0 ______________________________________ 95% O.sub.2 and 5% CO.sub.2 is bubbled through the solution, which is warmed to 37.degree. C. The pH is 7.4 and the preload on the vessel strip is 1.0 g. The isotonic contraction changes are detected using a lever arrangement and an HF modem (position sensor) from Hugo Sachs and recorded on a compensating recorder (BEC, Goerz Metrawatt SE 460). After equilibration for 1 hour, the experiment is begun. After the vessel strips have achieved their maximum sensitivity to 2.times.10.sup.-7 mol/l of bradykinin--bradykinin leads to a contraction of the vessel strips--the peptides are allowed to act for 10 minutes in each case in the doses 5.times.10.sup.-8 -1.times.10.sup.-5 mol/l and, after adding bradykinin again, the decrease in the effect of bradykinin as opposed to the control is compared. For the detection of a partial agonistic effect, the peptides are used in the doses 1.times.10.sup.-5 -1.times.10.sup.-3 mol/l. The IC.sub.50 values of some of the peptides according to the invention calculated from the dose-effect curves are shown in Table 1. TABLE 1 __________________________________________________________________________ Compound IC.sub.50 [M] __________________________________________________________________________ H-(D)-Arg--Arg--Hyp--Pro--Gly--Phe--Ser-(D)-Tic--Phe--Arg--OH 4.6 .times. 10.sup.-6 H-(D)-Arg--Arg--Hyp--Pro--Gly--Thia--Ser-(D)-Tic--Thia--Arg--OH 2.1 .times. 10.sup.-6 H-(D)-Arg--Arg--Pro--Hyp--Gly--Phe--Ser-(D)-Tic--Phe--Arg--OH 1.2 .times. 10.sup.-5 H-(D)-Arg--Arg--Hyp--Pro--Gly--Phe--Gly-(D)-Tic--Phe--Arg--OH 2.4 .times. 10.sup.-5 H-(D)-Arg--Arg--Pro--Hyp--Gly--Phe--Ser-(D)-Tic--Phe--Arg(Mtr)--OH 2.5 .times. 10.sup.-5 H-(D)-Arg--Arg--Hyp--Pro--Gly--Phe--Ser-(D)-Tic--Pro--Arg--OH 2.5 .times. 10.sup.-7 H-(D)-Arg--Arg--Hyp--Pro--Gly--Thia--Ser-(D)-Tic--Pro--Arg--OH 1.9 .times. 10.sup.-7 H-(D)-Arg--Arg--Hyp--Pro--Gly--Thia--Ser-(D)-Tic--Aoc--Arg--CH 5.6 .times. 10.sup.-8 H-(D)-Arg--Arg--Hyp--Pro--Gly--Thia--Ser--.beta.--Ala-(D)-Tic--Aoc--Arg--O H 1.7 .times. 10.sup.-6 H-(D)-Arg--Arg--Hyp--Pro--Gly--Thia--Ser--Gly-(D)-Tic--Aoc--Arg--OH 3.9 .times. 10.sup.-7 H-(D)-Arg--Arg--Hyp--Pro--Gly--Thia--Gly-(D)-Tic-(D,L)-Oic--Arg--OH 3.2 .times. 10.sup.-7 H-(D)-Arg-(D)-Arg--Hyp--Pro--Gly--Thia--Ser-(D)-Tic--Aoc--Arg--OH 4.8 .times. 10.sup.-7 H-(D)-Arg--Arg--Hyp--Pro--Gly--Thia--Ser-(D)-Tic--Tic--Arg--OH 1.7 .times. 10.sup.-7 H-(D)-Arg--Arg--Pro--Hyp--Gly--Thia--Ser-(D)-Tic--Aoc--A--rg--OH 1.1 .times. 10.sup.-8 H-(D)-Arg--Arg--Pro--Hyp--Gly--Phe--Ser-(D)-Tic--Aoc--Arg--OH 4.6 .times. 10.sup.-8 H-(D)-Tyr--Arg--Pro--Hyp--Gly--Thia--Ser-(D)-Tic--Aoc--Arg--OH 6.2 .times. 10.sup.-8 H-(D)-Arg--Arg--Pro--Hyp--Gly--Thia--Ser-(D)-Tic-(D)-Oic--Arg--OH 2.6 .times. 10.sup.-5 H-(D)-Arg--Arg--Pro--Hyp--Gly--Thia--Ser-(D)-Tic--Oic--Arg--OH 5.4 .times. 10.sup.-9 H-(D)-Arg--Lys--Pro--Hyp--Gly--Phe--Ser-(D)-Tic--Aoc--Arg--CH 3.2 .times. 10.sup.-7 H-(D)-Arg--Arg--Pro--Hyp--Gly--Phe--Ser-(D)-Tic--Oic--Arg--OH 6.8 .times. 10.sup.-9 H-(D)-Arg--Arg(NO.sub.2)--Pro--Hyp--Gly--Phe--Ser-(D)-Tic--Aoc--Arg--OH 6.4 .times. 10.sup.-8 H-(D)-Arg--Arg--Pro--Pro--Gly--Thia--Ser-(D)-Tic--Oic--Arg--OH 4.2 .times. 10.sup.-9 H-(D)-Arg--Pro--Hyp--Gly--Phe--Ser-(D)-Tic--Oic--Arg--OH 3.4 .times. 10.sup.-7 H--Arg(Tos)--Pro--Hyp--Gly--Phe--Ser-(D)-Tic--Oic--Arg--OH 3.0 .times. 10.sup.-8 H--Arg(Tos)--Pro--Hyp--Gly--Thia--Ser-(D)-Tic--Oic--Arg--OH 1.8 .times. 10.sup.-8 H-(D)-Arg--Arg--Pro--Hyp--Gly--Phe--Ser-(D)-Phe--Oic--Arg--OH 1.4 .times. 10.sup.-8 H-(D)-Arg--Arg--Pro--Hyp--Gly--Thia--Ser-(D)-Phe--Oic--Arg--OH 1.4 .times. 10.sup.-8 H-(D)-Arg--Arg--Pro--Pro--Gly--Phe--Ser-(D)-(p-Cl)Phe--Oic--Arg--OH 8 .times. 10.sup.-8 H-(D)-Arg--Arg--Pro--Hyp--Gly--Leu--Ser-(D)-Tic--Oic--Arg--OH 5.9 .times. 10.sup.-9 H-(D)-Arg--Arg--Pro--Hyp--Gly--Cha--Ser-(D)-Tic--Oic--Arg--OH 3.7 .times. 10.sup.-8 H-(D)-Arg--Arg--Pro--Hyp--Gly--Tbg--Ser-(D)-Tic--Oic--Arg--OH 6.0 .times. 10.sup.-6 __________________________________________________________________________ The therapeutic utility of the peptides according to the invention includes all pathological states which are mediated, caused or supported by bradykinin and bradykinin-related peptides. This includes, inter alia, traumas, such as wounds, burns, rashes, erythemas, edemas, angina, tonsillitis, arthritis, asthma, allergies, rhinitis, shock, inflammations, low blood pressure, pain, itching, pruritus, and changed sperm motility. The invention therefore also relates to the use of peptides of the formula I as medicaments, and to pharmaceutical preparations which contain these compounds. Pharmaceutical preparations contain an effective amount of the active substance of the formula I--individually or in combination--together with an inorganic or organic pharmaceutically utilizable excipient. Administration can be carried out enterally, parenterally, such as, for example, subcutaneously, i.m. or i.v., sublingually, epicutaneously, nasally, rectally, intravaginally, intrabuccally or by inhalation. The dosage of the active substance depends on the mammal species, the body weight, age and on the manner of administration. The pharmaceutical preparations of the present invention are prepared in solution, mixing, granulating or tablet coating processes known per se. For oral administration or application to the mucosa, the active compounds are mixed with the customary additives for this, such as excipients, stabilizers or inert diluents, and brought into suitable forms for administration, such as tablets, coated tablets, hard gelatin capsules, aqueous, alcoholic or oily suspensions or aqueous, alcoholic or oily solutions, by customary methods. Inert excipients which may be used are, for example, gum arabic, magnesia, magnesium carbonate, potassium phosphate, lactose, glucose, magnesium stearyl fumarate or starch, in particular maize starch. In this case, the preparation may be present both as dry and moist granules. Suitable oily excipients or solvents are, for example, vegetable or animal oils, such as sunflower oil and cod liver oil. A preparation for topical application may be present as an aqueous or oily solution, lotion, emulsion or gel, ointment or fatty ointment or, if possible, in spray form, it being possible to improve the adhesion, if desired, by addition of a polymer. For the intranasal form of administration, the compounds are mixed with the customary auxiliaries for this, such as stabilizers or inert diluents, and brought into suitable forms for administration, such as aqueous, alcoholic or oily suspensions or aqueous, alcoholic or oily solutions, by customary methods. Chelating agents, ethylenediamine-N,N,N',N'-tetraacetic acid, citric acid, tartaric acid or their salts may be added to aqueous intranasal preparations. Administration of the nasal solutions can be carried out by means of metered atomizers or as nasal drops, having a viscosity increasing component, or nasal gels or nasal creams. For administration by inhalation, atomizers or pressurized gas packs using inert carrier gases can be used. For intravenous, subcutaneous, epicutaneous or intradermal administration, the active compounds or their physiologicaLLy tolerable salts, if desired with the pharmaceutically customary auxiliaries, for example for isotonisizing or adjusting pH, and solubilizers, emulsifiers or other auxiliaries, are brought into solution, suspension or emulsion. Because of the short half-lives of some of the medicaments described in body fluids, the use of injectable sustained release preparations is efficient. Medicament forms which may be used are, for example, oily crystal suspensions, microcapsules, rods or implants, it being possible to synthesize the latter from tissue-compatible polymers, in particular biodegradable polymers, such as, for example, those based on polylactic acid/polyglycolic acid copolymers or human albumin. A suitable dose range for forms for topical application and administration by inhalation are solutions containing 0.01-5 mg/ml, and with forms for systemic administration 0.01-10 mg/kg is suitable. List of abbreviations: The abbreviations used for amino acids correspond to the three-letter code customary in peptide chemistry as described in Europ. J. Biochem. 138, 9 (1984). Additionally used abbreviations are listed below. ______________________________________ Acm Acetamidomethyl .epsilon.-Ahx .epsilon.-Aminohexanoyl Aoc cis, endo-2-Azabicyclo[3.3.0]octane-3-S- carbonyl Boc tert-Butyloxycarbonyl But tert-Butyl Bzl Benzyl CDF Chloro-(D)-phenylalanyl Cha Cyclohexylalanyl Chg Cyclohexylglycyl Cl-Z 4-Chlorobenzyloxycarbonyl DMF Dimethylformamide DOMT O-Methyl-(D)-threonyl Dnp 2,4-Dinitrophenyl Fmoc 9-Fluorenylmethoxycarbonyl MDY O-Methyl-(D)-tyrosyl Me Methyl 4-Mebzl 4-Methylbenzyl Mtr 4-Methoxy-2,3,6-trimethylphenylsulfonyl Mts Mesitylene-2-sulfonyl Nal 1- or 2-napthylalanyl NMP N-Methylpyrrolidine Npg Neopentylglycyl Oic cis-endo-octahydroindol-2-ylcarbonyl Opr Isoxazolidin-3-ylcarbonyl Pal 2- or 3-pyridylalanyl Pmc 2,2,5,7,8-Pentamethylchroman-6-sulfonyl Tbg tert-Butylglycyl Tcs 4-Methylphenylsulfonyl Thia 2-Thienylalanyl Tic 1,2,3,4-Tetrahydroisoquinolin-3-ylcarbonyl Trt Trityl ______________________________________ The following examples are intended to illustrate the preferred methods for solid phase synthesis of the peptides according to the invention, without limiting the invention thereto. In the following examples 1-195, the amino acid derivatives below were used: Fmoc-Arg(Mtr)-OH, Boc-(D)-Arg-OH, Fmoc-Arg(Pmc)-OH, Fmoc-Hyp-OH, Fmoc-Pro-OObt, Fmoc-Gly-OObt, Fmoc-Phe-OObt, Fmoc-Ser(tBu)-OObt, Fmoc-(D)-Tic-OH, Fmoc-Gln-OH, Fmoc-Aoc-OH, Fmoc-Thia-OH, Fmoc-Opr-OH, Fmoc-(D)-Asn-OH, Fmoc-.beta.-Ala-OH, Fmoc-Oic-OH. |
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