| TECHNOLOGY | is a proprietary and novel medicinal chemistry platform for the systematic transformation of peptide leads into peptidomimetics or small molecules. Biological and chemical methods are employed to identify lead peptides, whose pharmacophore information is extracted by means of SPOT™ and PepStar™ arrays. Subsequently, the pharmacophore information is used to identify small molecules with drug-like properties. In contrast to historical attempts (sequential modification of peptide structure, i.e. exchange of amide bonds, cyclization, and incorporation of turn structures etc.) the lead peptides or peptidomimetics serve only as information carriers to generate peptide-based SAR data. In a virtual screen small molecule scaffolds matching the pharmacophore model derived from the peptide-based SAR data are selected from a library of over 1 million compounds. Subsequent optimization of small molecule scaffolds is driven by a powerful team of experienced medicinal chemists. The PepMed™ transformation is supported by advanced NMR and X-ray techniques |
| COMPANY | This data is not available for free |
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