| RESEARCH |
Chemistry professor Scott J. Miller and coworkers at Boston College recently used library screening to find synthetic peptides that catalyze a range of highly selective enantioselective reactions such as phosphorylations, acyl transfers, and conjugate additions [J. Am. Chem. Soc., 124, 11653 (2002); C&EN, Oct. 8, 2001, page 9]. They've used combinatorial means to optimize the activities and selectivities of some of these peptide catalysts. Most recently, they extended the scope of the peptide catalysts to accelerating enantioselective C–C bond-forming reactions as well [Org. Lett., 5, 3741 (2003)]. |
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