| RESEARCH |
A potential step toward natural-product-like libraries of unprecedented diversity was made last week, when Schreiber and coworkers reported a strategy for making small-molecule libraries with all possible combinations of a set of both core skeletal structures and peripheral groups [Science, 302, 613 (2003)]. In most library syntheses, diverse peripheral groups are attached to a single core. The new approach achieves core and peripheral diversity simultaneously by using special core structures ("latent intermediates") that react with peripheral groups ("skeletal information elements") to generate diverse skeletons
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