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STUDY Sans protein, zebrafish biocrystals turn starry



The protein expressed by a newly discovered gene called starmaker has profound effects on the formation of inorganic crystals vital for balance and hearing in zebrafish, scientists in Europe report. Known as otoliths, the crystals, composed largely of calcium carbonate, are located in the fish's inner ears. Starmaker is homologous to a human gene, a mutant form of which can cause deafness. Authors and her colleagues damped down the action of starmaker in live fish, the otoliths changed from smooth, round stones into elaborate, star-shaped crystals (shown). The fish then had trouble orienting themselves
UPDATE 10.03
AUTHOR Theresa Nicolson, now at Oregon Health & Science University, in Portland
LITERATURE REF. [Science, 302, 282 (2003)].

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