| DESCRIPTION |
a triclosan-resistant flavoprotein called FabK in Streptococcus pneumoniae that can catalyze the same fatty acid biosynthesis reaction as FabI [Nature, 406, 145 (2000)]. In vitro, FabK was found to be more than 100-fold more resistant to triclosan than FabI. Organisms with only FabI are highly susceptible to triclosan, whereas those producing FabK--with or without FabI--are more resistant. The authors suggest that antimicrobial therapy based on blocking this pathway will need to be tailored for organisms according to their expression of FabI and FabK.
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