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COOPERATION Evotec Neurosciences And Takeda Enter Into
Drug Discovery Alliance In Alzheimer's Disease






Hamburg, Germany | Osaka, Japan - Evotec Neurosciences GmbH (ENS), a subsidiary
of Evotec OAI (Deutsche Borse: EVT, TecDAX 30) and Takeda Chemical Industries, Ltd.
(Takeda) today announced a four-year collaboration in the area of Alzheimer's disease
(AD). The two companies aim to identify and validate novel targets relating to
different aspects of the causes and progression of AD, with the goal of developing
innovative small molecule therapeutics.

ENS will grant Takeda access to its proprietary database of Alzheimer's disease-
related targets, and further validate selected target candidates for downstream drug
discovery programs. Takeda will make payments to Evotec Neurosciences of up to EUR
20 million covering database access fees, research funding and milestone payments
relating to the selection of targets for further drug discovery. Substantial milestones
would also be payable on the successful clinical development of compounds acting on
selected targets. Further financial details of the collaboration are not disclosed.

"We are delighted to start this extensive collaboration with Takeda, one of
the world's leading pharmaceutical companies. It is a major validation of Evotec
Neurosciences' innovative work to identify and validate drug targets to prevent or
treat Alzheimer's disease. Alzheimerfs affects millions of people in the developed
world and is becoming an ever-increasing challenge as the population ages," said
Dr. John Kemp, Chief Executive Officer of Evotec Neurosciences.

"The agreement signed with Takeda is an important validation of our strategy we
adopted in 1999, when we decided to increasingly focus Evotec OAI on drug discovery
and selectively invest in high-value indication-specific research programs together
with leading academic institutions in order to cover a large part of the discovery
value chain," said Joern Aldag, President and Chief Executive Officer of Evotec OAI.

"We are very much excited to enter into this collaboration with Evotec
Neurosciences. In choosing this partnership, we expect to be able to make full use
of the valuable database to accelerate our research for the creation of new drugs
for Alzheimer's disease. Takeda is pursuing every possibility for enhancing its R&D
pipeline, and promoting actively alliances with our partners so that we can utilize
outside resources efficiently in our research," said Takashi Soda, Ph.D., General
Manager of Takeda's Pharmaceutical Research Division.



UPDATE 01.08.03
COMPANY - Evotec Neurosciences GmbH
- Takeda Chemical Inds.

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