| COOPERATION |
- Eastern Virginia Medical School - U.S. Agency for Intl. Development |
| FORMULATION |
Vaginal formulation that optimizes both spermicidal & anti- HIV activities Novel water-soluble polymers have been developed for delivery of active agents to mucosal substrates. Called DCE (See Abbreviation), these polymers have great potential in drug delivery DCEs contain both cationic & hydrophobic substituents attached to a cellulose ether backbone. They were designed to adhere to mucous membranes. These membranes are anionic substrates, whether they are lining the eye, the GI tract, the lungs or the reproductive system. When the cationic material contacts the anionic mucosa, a complex is produced that forms a protective layer over the mucosa. It was found also that the polymers also sharply reduce the rate at which sperm travel. The sperm-impedance property makes it possible to formulate a vaginal contraceptive with lower concn (to minimize irritancy) of spermicides such as nonoxynol or benzalkonium chloride. To ensure antiviral protection dextran sulfate (virucide) is incorporated |
| STATUS | FDA cleared Phase I clinical trials |
| UPDATE | 06.99 |
| COMPANY | Integra |
| CONTACT | Brode George L.; Distinguished Research Fellow with Integra |
|
Want more information ? Interested in the hidden information ? Click here and do your request. |