| STUDY | The University of Pennsylvania groups and their colleagues, including Hidetoshi Kono at the Japan Atomic Energy Research Institute, Kyoto, also used scads to transform KcsA, a membrane-bound bacterial potassium-channel protein, into one that's water soluble. Their strategy was to make the protein's lipid-contacting side chains more polar while maintaining its structure and function. Though membrane proteins comprise a large fraction of drug targets, they are notoriously difficult to study experimentally. The group's computational methods may therefore make it possible to study these proteins' structure and biophysical properties in unprecedented detail |
| UPDATE | 10.03 |
| AUTHOR |
- DeGrado William F. (Uni. Pennsylvania) - Kono Hidetoshi (Japan Atomic Energy Research I. - Saven Jeffery G. (Uni. Pennsylvania) |
| LITERATURE REF. | This data is not available for free |
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