| STRUCTURE |
The first crystal structure of a peroxo-bridged complex of two different redox-active metals--iron and copper--has been obtained by a research team in Japan. Peroxo-bridged heme-copper complexes have been prepared by groups led by Kenneth D. Karlin of Johns Hopkins University, James P. Collman of Stanford University, and Yoshinori Naruta of Kyushu University. However, these complexes have not been isolated and characterized structurally because of the instability of the peroxo group and difficulties in growing single crystals of sufficient quality. By using steric protection around the peroxo bridge, Naruta and coworkers, including Takefumi Chishiro, Yuichi Shimazaki, and Fumito Tani, have now succeeded in isolating a peroxo-bridged heme-copper complex (shown) and characterizing it by X-ray crystallography [Angew. Chem. Int. Ed., 42, 2788 (2003)]. The structure reveals that the dioxygen binds to iron in a "side-on" configuration, with both oxygen atoms bound to iron but only one bound to copper. |
| UPDATE | 17.06.03 |
| AUTHOR |
Isolation and Crystal Structure of a Peroxo-Bridged Heme-Copper Complex Takefumi Chishiro 1, Yuichi Shimazaki, Dr. 1, Fumito Tani, Dr. 1, Yoshimitsu Tachi, Dr. 1, Yoshinori Naruta, Prof. Dr. 1 *, Satoru Karasawa, Dr. 2, Shinya Hayami, Dr. 3, Yonezo Maeda, Prof. Dr. 3 1Institute for Fundamental Research of Organic Chemistry, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan, Fax: (+81) 92-642-2715 2Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan 3Graduate School of Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan |
| LITERATURE REF. | Angew. Chem. Int. Ed., 42, p. 2788 (2003) |
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