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For example, he says, "we came up with a fluoride rinse that deposits a very high level of calcium fluoride--a moderately soluble fluoride mineral--at a reduced concentration of applied fluoride." According to Vogel, this rinse uses a mechanism whereby calcium and fluoride ions or calcium fluoride nuclei penetrate plaque, enamel, and oral tissue under conditions of high calcium fluoride saturation. These ions and nuclei then become trapped as they aggregate and grow.
"This approach is very promising because it makes the whole mouth a slow-release fluoride reservoir and because it suggests that highly effective reduced fluoride products could be developed," Vogel says. He notes that PRC recently received National Institutes of Health and ADA grants to develop fluoride rinses, dentifrices, and lozenges based on these studies
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