| TECHNOLOGY |
capillette system, augmented with thermocycling, for rapid DNA analysis by polymerase chain reaction technology. The capillette--a predispensed reagent cartridge--protects reagents stored separately. The reagents are released when a cap is pressed. In PCR analyses, the process of sample preparation through liquid handling to thermocycling to post-PCR analysis can be trimmed from a day to less than 15 minutes. Co.'s solution combines sample preparation into capillettes with rapid-time thermocycler detection. "This is the big step for us." PCR analysis, he says, usually involves time-consuming heating and cooling. In 1999, the company built a centrifuge for the PCR process that uses superconvection at 10,000 times the force of gravity to speed up the movement of heated and cooled material, depending upon the phase of the process. An infrared lamp is the heat source. "We want not only to heat and cool but to monitor each step as well. Then a customer can quantify the results." "But it is also a solution for liquids handling. It is too easy now to introduce contaminants or to forget reagents or add too much reagent, and this is one reason PCR is not too successful in diagnostics: because of contamination problems." "We have taken the strategy of only going for partnering. We are developing technology, not marketing experts. So we want to partner with companies with a marketing organization." |
| UPDATE | 06.03 |
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