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In October 2000, the National Institute of Environmental Health Sciences (NIEHS) peer reviewed all low-dose studies that had been completed on BPA. The peer review panel concluded that several studies "provide credible evidence for low-dose effects of bisphenol A. These include increased prostate weight in male mice at six months of age and advanced puberty in female mice after in utero exposure to 2 or 20 µg per kg per day, and low-dose effects on uterine growth and serum prolactin levels that occurred in F344 rats ... exposed to 0.5 mg per kg per day." The NIEHS peer review panel also decided that "discrepancies in experimental outcomes among studies showing positive and negative effects of BPA may have been due to different diets with differing background levels of phytoestrogens, differences in strains of animals that were used, differences in dosing regimen, and differences in housing of animals (singly versus group)." However, it also cautioned that a low-dose effect of BPA "has not been conclusively established as a general or reproducible finding." As a consequence, it recommended that the current testing paradigm used for assessing reproductive and developmental toxicity should be revisited. |
| UPDATE | 05.03 |
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