| SUBJECT |
Computations have also helped author, design nanoinstruments for measuring DNA deformation. DNA-protein complexes, ubiquitous in biology, form flexible structures that are difficult to study. Author's method involves using a technique known as fluorescence resonance energy transfer (FRET) to determine distances between donor and acceptor dyes attached to molecules. To test their method, Author's group synthesized DNA strands with bulges introduced at points along the helices and dye molecules at the ends. They obtained nuclear magnetic resonance structures of the bulge and then created computational models of the positions of the dyes at the ends of the DNA. They were then able to use the FRET data, combined with the other information, to reveal "even subtle changes" in these large molecules. |
| UPDATE | 04.03 |
| AUTHOR | This data is not available for free |
| LITERATURE REF. | This data is not available for free |
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