| TECHNOLOGY |
Co.'s technology is based on the concept of transdifferentiation. Early embryonic cells have the ability to develop into any cell type in the body. As development proceeds, cells acquire a program that directs the fate and function of the cell. Co.'s research has demonstrated that this program can be replaced with a different program, in effect, altering the function of the cell. In Co.'s system, healthy mature cells from a patient are converted into, or example, insulin-producing cells using a proprietary technology. The reprogrammed cells can be transplanted back into the patient without eliciting immune rejection. Co.'s reprogramming strategy entails the reversible permeabilization of cells (for example SKIN cells) from a patient's biopsy. Cellular function is reprogrammed by incubation of the permeabilized cells in an extract prepared from, a desired target cell type. The target cell type may be insulin-producing Beta cells, cardiac cells, etc. Components necessary to turn on specific genes diffuse into the permeabilized skin cells and are taken up by the nucleus. The reprogrammed cells are resealed and transplanted back into the patient. There are many advantages of the Co. system. The technology can be used to produce a wide variety of different cell types for many different therapeutic applications. Co.'s scientists have demonstrated the effectiveness of this technology for producing islet cells, immune cells, neural cells and cardiac cells. The technology works efficiently and quickly. The reprogramming process can be done on batches of cells and takes only a few hours. Most importantly, the donor cells are obtained from the patient. Consequently, the cells will not be rejected when transplanted back into the patient so there is no need for immune suppression treatments. Also, potential viral transmission from donated tissue is avoided. |
| UPDATE | 05.02 |
| COMPANY | This data is not available for free |
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