| PREPARATION | Ji pointed out that the chiral tertiary aminonaphthol is not only effective but also easy to prepare by direct condensation of (S)-N,-dimethylbenzylamine, 2-naphthol, and benzaldehyde without need of solvent. The product precipitates when methanol is added to the mixture and can be used directly in asymmetric alkenyl-zinc additions without further purification. The operational simplicity makes the ligand attractive for large-scale applications, Ji said |
| UPDATE | 04.03 |
| USES |
Chiral allyl alcohols are key intermediates in the synthesis of natural products and biologically active compounds, yet effective ligands for asymmetric alkenylzinc additions are few. |
| AUTHOR | Hong Kong Polytechnic University's Ji Jian-Xin |
| LITERATURE REF. | This data is not available for free |
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