| DESCRIPTION |
Five independent physicochemical stages govern exocytosis, Amatore said. In his presentation, he focused on the stages in which the vesicle docks to the cell membrane, forming a fusion pore, and in which the vesicle and cell membranes fully fuse. These stages affect the shape of the spikes observed during electrochemical monitoring of neurotransmitters. When the fusion pore forms, a small amount of the vesicle contents is released, with a large spike of released material following full fusion. Amatore pointed out that in electrochemical monitoring there is not always a sharp transition between the fusion pore and full fusion
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