Main > PHARMA. > Chiral Pharmaceuticals > Carbohydrate s Chiral Pool. > Approach Discussion.

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OBSERVATION'S to mastering carbohydrate complexity at the Chiral USA 2000 symposium in Boston in May. "The 'chiral pool' approach to obtaining optically active molecules for commercial-scale synthesis has several advantages," he said, "the main ones being that the absolute configuration of the chiral centers can be known and [that] the optical purity of the products is usually very high.


"Carbohydrates are key components of the chiral pool," he went on, "and are extremely promising candidate materials from which a base of advanced synthetic intermediates can be derived. They are among the most abundant materials on earth and are often obtainable in a pure state. They are also a renewable resource."

But there is a downside: "Unfortunately, carbohydrates are extremely structurally dense with a high degree of redundant--hydroxyl group--functionality."

UPDATE 07.00
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